The study of protein-ligand interactions is fundamental to the understanding of biological systems and is at the heart of the drug discovery process. There are many biophysical methods available to study protein-ligand interactions that span from calorimetric techniques to spectroscopic and structural methods, including modeling. Young researchers are usually familiar with one or more of these methods but often do not have the opportunity to address the problem from an integrated structural biology perspective.
The second edition of this course is stimulated by the high number of applicants of its first edition (October 6-12, 2014) and builds on the experience gained by the tutors and the extremely positive feedback of the participants, namely that the course would have an impact in their research.
Therefore our main objective is not only to continue to illustrate but also to reinforce the added value of a structural biology approach to the study of protein-ligand interactions. In this edition this will be achieved by introducing a new core methodology; Molecular Modeling, to be combined with the methods of the first edition, X-ray Crystallography, NMR, EPR, Carbohydrate Microarrays and ITC, always explored from a hands-on perspective, giving emphasis to their limitations and complementarities.
The call for applications is presently closed.