Service / Technology Type

Analytical Ultracentrifugation (AUC)

Study the size and shape of macromolecules in solution to facilitate structural determination of large proteins

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Details

Analytical ultracentrifugation (AUC) is a powerful technique for the characterisation of macromolecules and macromolecular self- and hetero-association processes in solution. Two types of complementary experiments, sedimentation velocity and sedimentation equilibrium, can be performed in an analytical ultracentrifuge which is a high-speed centrifuge equipped with an optical detection system. The observation of macromolecules or macromolecular complexes sedimentation gives access to their hydrodynamic and thermodynamic properties, including their size, shape, molar mass, degree of heterogeneity, oligomeric state, stoichiometry, and binding constants.

Service/Technology Instances

Analytical Ultracentrifugation (AUC)

Analytical Ultracentrifugation (AUC) Experts

Christine Ebel
Christine Ebel
Institut de Biologie Structurale
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Robert Gilbert
Robert Gilbert
Centre for Medicines Discovery (CMD), University of Oxford
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