The center offers access for three-dimensional structure determination using cryo-electron microscopy (cryo-EM). The centre has expertise in all aspects of single particle analysis from the automated acquisition of large data sets to image analysis . Access to the following instrumentation is provided: The Titan Krios cryo electron microscope equiped with a CMOS (FEI FALCON 4K*4K) high-sensitivity direct electron detector camera. The Tecnai F30 Polara cryo electron microscope allows high-resolution SPA and CET automated data collection. The Tecnai F20 is equipped with a FEG operated at 100keV or 200keV.