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Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Mansilla A, Chaves-Sanjuan A, Campillo NE, Semelidou O, Martínez-González L, Infantes L, González-Rubio JM, Gil C, Conde S, Skoulakis EM, Ferrús A, Martínez A, Sánchez-Barrena MJ,
Proc. Natl. Acad. Sci. U.S.A. Jan 2017

Nanobodies to Study G Protein-Coupled Receptor Structure and Function.
Manglik A, Kobilka BK, Steyaert J,
Annu. Rev. Pharmacol. Toxicol. Jan 2017

Cryo-EM study of start codon selection during archaeal translation initiation.
Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y,
Nat Commun Nov 2016

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.
Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR,
Proc. Natl. Acad. Sci. U.S.A. Nov 2016

Structure of AP205 Coat Protein Reveals Circular Permutation in ssRNA Bacteriophages.
Shishovs M, Rumnieks J, Diebolder C, Jaudzems K, Andreas LB, Stanek J, Kazaks A, Kotelovica S, Akopjana I, Pintacuda G, Koning RI, Tars K,
J. Mol. Biol. Oct 2016

Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.
Claes K, Vandewalle K, Laukens B, Laeremans T, Vosters O, Langer I, Parmentier M, Steyaert J, Callewaert N,
ACS Synth Biol Oct 2016

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation.
Sharp TH, Faas FG, Koster AJ, Gros P,
J. Struct. Biol. Sep 2016

Structure of a human pre-40S particle points to a role for RACK1 in the final steps of 18S rRNA processing.
Larburu N, Montellese C, Kutay U, Gleizes PE, Plisson-Chastang C,
Nucleic Acids Res. Sep 2016

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Zhao Y, Ren J, Harlos K, Jones DM, Zeltina A, Bowden TA, Padilla-Parra S, Fry EE, Stuart DI,
Nature Jul 2016

The democratization of cryo-EM.
Stuart DI, Subramaniam S, Abrescia NG,
Nat. Methods Jul 2016

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y,
Mol. Cell Jul 2016

Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Arenz S, Juette MF, Graf M, Nguyen F, Huter P, Polikanov YS, Blanchard SC, Wilson DN,
Proc. Natl. Acad. Sci. U.S.A. Jul 2016

Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State.
Yewdall NA, Venugopal H, Desfosses A, Abrishami V, Yosaatmadja Y, Hampton MB, Gerrard JA, Goldstone DC, Mitra AK, Radjainia M,
Structure Jul 2016

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.
Valsecchi WM, Cousido-Siah A, Defelipe LA, Mitschler A, Podjarny A, Santos J, Delfino JM,
Biochim. Biophys. Acta Jun 2016

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.
von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S,
Nature Jun 2016

Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces.
Celler K, Koning RI, Willemse J, Koster AJ, van Wezel GP,
Nat Commun Jun 2016

Initiation of T cell signaling by CD45 segregation at 'close contacts'.
Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJ, Klenerman D, Aricescu AR, Davis SJ,
Nat. Immunol. May 2016

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy.
de la Rosa-Trevín JM, Quintana A, Del Cano L, Zaldívar A, Foche I, Gutiérrez J, Gómez-Blanco J, Burguet-Castell J, Cuenca-Alba J, Abrishami V, Vargas J, Otón J, Sharov G, Vilas JL, Navas J, Conesa P, Kazemi M, Marabini R, Sorzano CO, Carazo JM,
J. Struct. Biol. Apr 2016

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A,
Nat. Struct. Mol. Biol. Apr 2016

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W,
J. Med. Chem. Mar 2016

Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase.
Sicoli G, Mouesca JM, Zeppieri L, Amara P, Martin L, Barra AL, Fontecilla-Camps JC, Gambarelli S, Nicolet Y,
Science Mar 2016

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution.
Howard EI, Guillot B, Blakeley MP, Haertlein M, Moulin M, Mitschler A, Cousido-Siah A, Fadel F, Valsecchi WM, Tomizaki T, Petrova T, Claudot J, Podjarny A,
IUCrJ Mar 2016

Basic facts and perspectives of Overhauser DNP NMR.
Ravera E, Luchinat C, Parigi G,
J. Magn. Reson. Mar 2016

Monitoring of the retinoic acid receptor-retinoid X receptor dimerization upon DNA binding by native mass spectrometry.
Nguyen-Huynh NT, Osz J, Peluso-Iltis C, Rochel N, Potier N, Leize-Wagner E,
Biophys. Chem. Mar 2016

Sequential protein expression and selective labeling for in-cell NMR in human cells.
Luchinat E, Secci E, Cencetti F, Bruni P,
Biochim. Biophys. Acta Mar 2016

Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein.
Belorusova AY, Osz J, Petoukhov MV, Peluso-Iltis C, Kieffer B, Svergun DI, Rochel N,
Biochemistry Mar 2016

Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.
Peyrassol X, Laeremans T, Gouwy M, Lahura V, Debulpaep M, Van Damme J, Steyaert J, Parmentier M, Langer I,
J. Immunol. Mar 2016

The Electron Microscopy eXchange (EMX) initiative.
Marabini R, Ludtke SJ, Murray SC, Chiu W, de la Rosa-Trevín JM, Patwardhan A, Heymann JB, Carazo JM,
J. Struct. Biol. Mar 2016

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels.
Lepage ML, Schneider JP, Bodlenner A, Meli A, De Riccardis F, Schmitt M, Tarnus C, Nguyen-Huynh NT, Francois YN, Leize-Wagner E, Birck C, Cousido-Siah A, Podjarny A, Izzo I, Compain P,
Chemistry Mar 2016

A critical assessment of methods to recover information from averaged data.
Ravera E, Sgheri L, Parigi G, Luchinat C,
Phys Chem Chem Phys Mar 2016

Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations.
Andrałojć W, Ravera E, Salmon L, Parigi G, Al-Hashimi HM, Luchinat C,
Phys Chem Chem Phys Mar 2016

Solid-State NMR of PEGylated Proteins.
Ravera E, Ciambellotti S, Cerofolini L, Martelli T, Kozyreva T, Bernacchioni C, Giuntini S, Fragai M, Turano P, Luchinat C,
Angew. Chem. Int. Ed. Engl. Mar 2016

Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure.
Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C,
J. Am. Chem. Soc. Mar 2016

How to tackle protein structural data from solution and solid state: An integrated approach.
Carlon A, Ravera E, Andrałojć W, Parigi G, Murshudov GN, Luchinat C,
Prog Nucl Magn Reson Spectrosc Mar 2016

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.
Cerofolini L, Amar S, Lauer JL, Martelli T, Fragai M, Luchinat C, Fields GB,
Sci Rep Jan 2016

Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography.
Sherman S, Kirchenbuechler D, Nachmias D, Tamir A, Werner S, Elbaum M, Elia N,
Sci Rep Jan 2016

Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.
Wijckmans E, Nys M, Debaveye S, Brams M, Pardon E, Willegems K, Bertrand D, Steyaert J, Efremov R, Ulens C,
PLoS ONE Jan 2016

Production of unstable proteins through the formation of stable core complexes.
Levy N, Eiler S, Pradeau-Aubreton K, Maillot B, Stricher F, Ruff M,
Nat Commun Jan 2016

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.
Stupfler B, Birck C, Séraphin B, Mauxion F,
Nat Commun Jan 2016

Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway.
Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F,
J. Biol. Chem. Jan 2016

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, Travé G, Zanier K,
Nature Jan 2016

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.
Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J,
Sci Rep Jan 2016

Gbp2 interacts with THO/TREX through a novel type of RRM domain.
Martínez-Lumbreras S, Taverniti V, Zorrilla S, Séraphin B, Pérez-Cañadillas JM,
Nucleic Acids Res. Jan 2016

Atomic-Level Quality Assessment of Enzymes Encapsulated in Bioinspired Silica.
Martelli T, Ravera E, Louka A, Cerofolini L, Hafner M, Fragai M, Becker CF, Luchinat C,
Chemistry Jan 2016

Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions.
Vavřinská A, Zelinka J, Šebera J, Sychrovský V, Fiala R, Boelens R, Sklenář V, Trantírek L,
J. Biomol. NMR Jan 2016

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5.
Timucin E, Cousido-Siah A, Mitschler A, Podjarny A, Sezerman OU,
Proteins Jan 2016

Volta phase plate cryo-EM of the small protein complex Prx3.
Khoshouei M, Radjainia M, Phillips AJ, Gerrard JA, Mitra AK, Plitzko JM, Baumeister W, Danev R,
Nat Commun Jan 2016

Temperature and pH dependence of DNA ejection from archaeal lemon-shaped virus His1.
Hanhijärvi KJ, Ziedaite G, Hæggström E, Bamford DH,
Eur. Biophys. J. Jan 2016

(1)H-detected solid-state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials characterization.
Ravera E, Cerofolini L, Martelli T, Louka A, Fragai M, Luchinat C,
Sci Rep Jan 2016

Helical Symmetry of Nucleic Acids: Obstacle or Help in Structure Solution?
Urzhumtsev A, Urzhumtseva L, Baumann U,
Methods Mol. Biol. Jan 2016

Arginine 66 Controls Dark-State Formation in Green-to-Red Photoconvertible Fluorescent Proteins.
Berardozzi R, Adam V, Martins A, Bourgeois D,
J. Am. Chem. Soc. Jan 2016

Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P,
Nat Commun Jan 2016

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.
Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G,
Nat Commun Jan 2016

Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ.
Koning RI, Gomez-Blanco J, Akopjana I, Vargas J, Kazaks A, Tars K, Carazo JM, Koster AJ,
Nat Commun Jan 2016

Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis.
Shakeel S, Westerhuis BM, Domanska A, Koning RI, Matadeen R, Koster AJ, Bakker AQ, Beaumont T, Wolthers KC, Butcher SJ,
Nat Commun Jan 2016

Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.
Banci L, Camponeschi F, Ciofi-Baffoni S, Muzzioli R,
J. Am. Chem. Soc. Dec 2015

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.
Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N,
Cell Rep Dec 2015

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.
Ruiz FX, Cousido-Siah A, Porté S, Domínguez M, Crespo I, Rechlin C, Mitschler A, de Lera ÁR, Martín MJ, de la Fuente JÁ, Klebe G, Parés X, Farrés J, Podjarny A,
ChemMedChem Dec 2015

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.
Diebolder CA, Halff EF, Koster AJ, Huizinga EG, Koning RI,
Structure Dec 2015

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.
Melesina J, Robaa D, Pierce RJ, Romier C, Sippl W,
J. Mol. Graph. Model. Nov 2015

Haloarchaeal virus morphotypes.
Atanasova NS, Bamford DH, Oksanen HM,
Biochimie Nov 2015

Sulfolobus Spindle-Shaped Virus 1 Contains Glycosylated Capsid Proteins, a Cellular Chromatin Protein, and Host-Derived Lipids.
Quemin ER, Pietilä MK, Oksanen HM, Forterre P, Rijpstra WI, Schouten S, Bamford DH, Prangishvili D, Krupovic M,
J. Virol. Nov 2015

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.
Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R,
Nat. Struct. Mol. Biol. Oct 2015

Insight into the Assembly of Viruses with Vertical Single β-barrel Major Capsid Proteins.
Gil-Carton D, Jaakkola ST, Charro D, Peralta B, Castaño-Díez D, Oksanen HM, Bamford DH, Abrescia NG,
Structure Oct 2015

N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin.
Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R, Winkelmann J,
Nat. Chem. Biol. Oct 2015

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Rostislavleva K, Soler N, Ohashi Y, Zhang L, Pardon E, Burke JE, Masson GR, Johnson C, Steyaert J, Ktistakis NT, Williams RL,
Science Oct 2015

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.
Beckert B, Kedrov A, Sohmen D, Kempf G, Wild K, Sinning I, Stahlberg H, Wilson DN, Beckmann R,
Nat. Struct. Mol. Biol. Oct 2015

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE,
Nucleic Acids Res. Sep 2015

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
Chari A, Haselbach D, Kirves JM, Ohmer J, Paknia E, Fischer N, Ganichkin O, Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H,
Nat. Methods Sep 2015

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer.
Postupalenko V, Desplancq D, Orlov I, Arntz Y, Spehner D, Mely Y, Klaholz BP, Schultz P, Weiss E, Zuber G,
Angew. Chem. Int. Ed. Engl. Sep 2015

Biosilica-Entrapped Enzymes Studied by Using Dynamic Nuclear-Polarization-Enhanced High-Field NMR Spectroscopy.
Ravera E, Michaelis VK, Ong TC, Keeler EG, Martelli T, Fragai M, Griffin RG, Luchinat C,
Chemphyschem Aug 2015

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles.
Van Benschoten AH, Afonine PV, Terwilliger TC, Wall ME, Jackson CJ, Sauter NK, Adams PD, Urzhumtsev A, Fraser JS,
Acta Crystallogr. D Biol. Crystallogr. Aug 2015

Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex.
Nguyen-Huynh NT, Sharov G, Potel C, Fichter P, Trowitzsch S, Berger I, Lamour V, Schultz P, Potier N, Leize-Wagner E,
Protein Sci. Aug 2015

Non-structural proteins P17 and P33 are involved in the assembly of the internal membrane-containing virus PRD1.
Karttunen J, Mäntynen S, Ihalainen TO, Bamford JK, Oksanen HM,
Virology Aug 2015

Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianférani S, Cavarelli J,
J. Struct. Biol. Aug 2015

From deep TLS validation to ensembles of atomic models built from elemental motions.
Urzhumtsev A, Afonine PV, Van Benschoten AH, Fraser JS, Adams PD,
Acta Crystallogr. D Biol. Crystallogr. Aug 2015

Programming new geometry restraints: parallelity of atomic groups.
Sobolev OV, Afonine PV, Adams PD, Urzhumtsev A,
J Appl Crystallogr Aug 2015

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Fadel F, Zhao Y, Cachau R, Cousido-Siah A, Ruiz FX, Harlos K, Howard E, Mitschler A, Podjarny A,
Acta Crystallogr. D Biol. Crystallogr. Jul 2015

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.
Fanfrlík J, Ruiz FX, Kadlčíková A, Řezáč J, Cousido-Siah A, Mitschler A, Haldar S, Lepšík M, Kolář MH, Majer P, Podjarny AD, Hobza P,
ACS Chem. Biol. Jul 2015

HDAC8: a multifaceted target for therapeutic interventions.
Chakrabarti A, Oehme I, Witt O, Oliveira G, Sippl W, Romier C, Pierce RJ, Jung M,
Trends Pharmacol. Sci. Jul 2015

Information content of long-range NMR data for the characterization of conformational heterogeneity.
Andrałojć W, Berlin K, Fushman D, Luchinat C, Parigi G, Ravera E, Sgheri L,
J. Biomol. NMR Jul 2015

Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein.
Rippa V, Santini L, Lo Surdo P, Cantini F, Veggi D, Gentile MA, Grassi E, Iannello G, Brunelli B, Ferlicca F, Palmieri E, Pallaoro M, Aricò B, Banci L, Pizza M, Scarselli M,
Clin. Vaccine Immunol. Jul 2015

Structure and function insights into the NuRD chromatin remodeling complex.
Torchy MP, Hamiche A, Klaholz BP,
Cell. Mol. Life Sci. Jul 2015

Structural basis for retroviral integration into nucleosomes.
Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P,
Nature Jul 2015

Stable mammalian producer cell lines for structural biology.
Büssow K,
Curr. Opin. Struct. Biol. Jun 2015

CTF Challenge: Result summary.
Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, Quintana A, Sorzano CO, Stahlberg H, Vargas J, Voss NR, Chiu W, Carazo JM,
J. Struct. Biol. Jun 2015

Structural characterization of metal binding to a cold-adapted frataxin.
Noguera ME, Roman EA, Rigal JB, Cousido-Siah A, Mitschler A, Podjarny A, Santos J,
J. Biol. Inorg. Chem. Jun 2015

Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands.
Cerofolini L, Amato J, Borsi V, Pagano B, Randazzo A, Fragai M,
J. Mol. Recognit. Jun 2015

Haloviruses of archaea, bacteria, and eukaryotes.
Atanasova NS, Oksanen HM, Bamford DH,
Curr. Opin. Microbiol. Jun 2015

Structural virology. Near-atomic cryo-EM structure of the helical measles virus nucleocapsid.
Gutsche I, Desfosses A, Effantin G, Ling WL, Haupt M, Ruigrok RW, Sachse C, Schoehn G,
Science May 2015

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Newman JA, Savitsky P, Allerston CK, Bizard AH, Özer Ö, Sarlós K, Liu Y, Pardon E, Steyaert J, Hickson ID, Gileadi O,
Nucleic Acids Res. May 2015

Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA.
Školáková P, Foldynová-Trantírková S, Bednářová K, Fiala R, Vorlíčková M, Trantírek L,
Nucleic Acids Res. May 2015

New enveloped dsRNA phage from freshwater habitat.
Mäntynen S, Laanto E, Kohvakka A, Poranen MM, Bamford JK, Ravantti JJ,
J. Gen. Virol. May 2015

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form.
Leone P, Bebeacua C, Opota O, Kellenberger C, Klaholz B, Orlov I, Cambillau C, Lemaitre B, Roussel A,
J. Biol. Chem. May 2015

BRET evidence that β2 adrenergic receptors do not oligomerize in cells.
Lan TH, Liu Q, Li C, Wu G, Steyaert J, Lambert NA,
Sci Rep May 2015

Structure of the human 80S ribosome.
Khatter H, Myasnikov AG, Natchiar SK, Klaholz BP,
Nature Apr 2015

NMR of sedimented, fibrillized, silica-entrapped and microcrystalline (metallo)proteins.
Ravera E, Schubeis T, Martelli T, Fragai M, Parigi G, Luchinat C,
J. Magn. Reson. Apr 2015

Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.
Skálová T, Bláha J, Harlos K, Dušková J, Stránský J, Hašek J, Vaněk O, Dohnálek J,
Acta Crystallogr. D Biol. Crystallogr. Mar 2015

Alignment of direct detection device micrographs using a robust Optical Flow approach.
Abrishami V, Vargas J, Li X, Cheng Y, Marabini R, Sorzano CÓ, Carazo JM,
J. Struct. Biol. Mar 2015

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Uchikawa E, Natchiar KS, Han X, Proux F, Roblin P, Zhang E, Durand A, Klaholz BP, Dock-Bregeon AC,
Nucleic Acids Res. Mar 2015

FEM: feature-enhanced map.
Afonine PV, Moriarty NW, Mustyakimov M, Sobolev OV, Terwilliger TC, Turk D, Urzhumtsev A, Adams PD,
Acta Crystallogr. D Biol. Crystallogr. Mar 2015

Structure of the F-actin-tropomyosin complex.
von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S,
Nature Mar 2015

A conserved amphipathic helix is required for membrane tubule formation by Yop1p.
Brady JP, Claridge JK, Smith PG, Schnell JR,
Proc. Natl. Acad. Sci. U.S.A. Mar 2015

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N,
Cell Rep Mar 2015

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling.
Pegeot M, Sadir R, Eriksson I, Kjellen L, Simorre JP, Gans P, Lortat-Jacob H,
Glycobiology Mar 2015

OrthoInspector 2.0: Software and database updates.
Linard B, Allot A, Schneider R, Morel C, Ripp R, Bigler M, Thompson JD, Poch O, Lecompte O,
Bioinformatics Mar 2015

Insect cells-baculovirus system for the production of difficult to express proteins.
Osz-Papai J, Radu L, Abdulrahman W, Kolb-Cheynel I, Troffer-Charlier N, Birck C, Poterszman A,
Methods Mol. Biol. Jan 2015

Hepatitis A virus and the origins of picornaviruses.
Wang X, Ren J, Gao Q, Hu Z, Sun Y, Li X, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE,
Nature Jan 2015

Conformation transitions of eukaryotic polyribosomes during multi-round translation.
Afonina ZA, Myasnikov AG, Shirokov VA, Klaholz BP, Spirin AS,
Nucleic Acids Res. Jan 2015

Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Trowitzsch S, Viola C, Scheer E, Conic S, Chavant V, Fournier M, Papai G, Ebong IO, Schaffitzel C, Zou J, Haffke M, Rappsilber J, Robinson CV, Schultz P, Tora L, Berger I,
Nat Commun Jan 2015

Live cell immunogold labelling of RNA polymerase II.
Orlov I, Schertel A, Zuber G, Klaholz B, Drillien R, Weiss E, Schultz P, Spehner D,
Sci Rep Jan 2015

Mechanism of β-lactam action in Streptococcus pneumoniae: the piperacillin paradox.
Philippe J, Gallet B, Morlot C, Denapaite D, Hakenbeck R, Chen Y, Vernet T, Zapun A,
Antimicrob. Agents Chemother. Jan 2015

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Jacomin AC, Bescond A, Soleilhac E, Gallet B, Schoehn G, Fauvarque MO, Taillebourg E,
PLoS ONE Jan 2015

Genomic Analysis and Isolation of RNA Polymerase II Dependent Promoters from Spodoptera frugiperda.
Bleckmann M, Fritz MH, Bhuju S, Jarek M, Schürig M, Geffers R, Benes V, Besir H, van den Heuvel J,
PLoS ONE Jan 2015

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.
Giménez-Dejoz J, Kolář MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlík J, Parés X, Farrés J, Porté S,
PLoS ONE Jan 2015

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution.
Quade N, Boehringer D, Leibundgut M, van den Heuvel J, Ban N,
Nat Commun Jan 2015

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.
Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P,
PLoS ONE Jan 2015

Structural and functional investigation of flavin binding center of the NqrC subunit of sodium-translocating NADH:quinone oxidoreductase from Vibrio harveyi.
Borshchevskiy V, Round E, Bertsova Y, Polovinkin V, Gushchin I, Ishchenko A, Kovalev K, Mishin A, Kachalova G, Popov A, Bogachev A, Gordeliy V,
PLoS ONE Jan 2015

Schistosome sirtuins as drug targets.
Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ,
Future Med Chem Jan 2015

The production of multiprotein complexes in insect cells using the baculovirus expression system.
Abdulrahman W, Radu L, Garzoni F, Kolesnikova O, Gupta K, Osz-Papai J, Berger I, Poterszman A,
Methods Mol. Biol. Jan 2015

Characterization and production of protein complexes by co-expression in Escherichia coli.
Haffke M, Marek M, Pelosse M, Diebold ML, Schlattner U, Berger I, Romier C,
Methods Mol. Biol. Jan 2015

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
Marek M, Oliveira G, Pierce RJ, Jung M, Sippl W, Romier C,
Future Med Chem Jan 2015

Structural basis of natural promoter recognition by the retinoid X nuclear receptor.
Osz J, McEwen AG, Poussin-Courmontagne P, Moutier E, Birck C, Davidson I, Moras D, Rochel N,
Sci Rep Jan 2015

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
Sohmen D, Chiba S, Shimokawa-Chiba N, Innis CA, Berninghausen O, Beckmann R, Ito K, Wilson DN,
Nat Commun Jan 2015

A posteriori correction of camera characteristics from large image data sets.
Afanasyev P, Ravelli RB, Matadeen R, De Carlo S, van Duinen G, Alewijnse B, Peters PJ, Abrahams JP, Portugal RV, Schatz M, van Heel M,
Sci Rep Jan 2015

Architecture and conformational switch mechanism of the ryanodine receptor.
Efremov RG, Leitner A, Aebersold R, Raunser S,
Nature Jan 2015

A structural model of the genome packaging process in a membrane-containing double stranded DNA virus.
Hong C, Oksanen HM, Liu X, Jakana J, Bamford DH, Chiu W,
PLoS Biol. Dec 2014

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10.
Cousido-Siah A, Ruiz FX, Crespo I, Porté S, Mitschler A, Parés X, Podjarny A, Farrés J,
Chem. Biol. Interact. Dec 2014

Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans.
Reiser JB, Legoux F, Gras S, Trudel E, Chouquet A, Léger A, Le Gorrec M, Machillot P, Bonneville M, Saulquin X, Housset D,
J. Immunol. Dec 2014

"CON-CON" assignment strategy for highly flexible intrinsically disordered proteins.
Piai A, Hošek T, Gonnelli L, Zawadzka-Kazimierczuk A, Koźmiński W, Brutscher B, Bermel W, Pierattelli R, Felli IC,
J. Biomol. NMR Dec 2014

G-triplex structure and formation propensity.
Cerofolini L, Amato J, Giachetti A, Limongelli V, Novellino E, Parrinello M, Fragai M, Randazzo A, Luchinat C,
Nucleic Acids Res. Dec 2014

Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination.
Boland C, Li D, Shah ST, Haberstock S, Dötsch V, Bernhard F, Caffrey M,
Cell. Mol. Life Sci. Dec 2014

Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery.
Brancaccio D, Gallo A, Mikolajczyk M, Zovo K, Palumaa P, Novellino E, Piccioli M, Ciofi-Baffoni S, Banci L,
J. Am. Chem. Soc. Nov 2014

Structural insights of proteins in sub-cellular compartments: In-mitochondria NMR.
Barbieri L, Luchinat E, Banci L,
Biochim. Biophys. Acta Nov 2014

Reversible amyloid fiber formation in the N terminus of androgen receptor.
Asencio-Hernández J, Ruhlmann C, McEwen A, Eberling P, Nominé Y, Céraline J, Starck JP, Delsuc MA,
Chembiochem Nov 2014

Mapping the deubiquitination module within the SAGA complex.
Durand A, Bonnet J, Fournier M, Chavant V, Schultz P,
Structure Nov 2014

Nuclear position dictates DNA repair pathway choice.
Lemaître C, Grabarz A, Tsouroula K, Andronov L, Furst A, Pankotai T, Heyer V, Rogier M, Attwood KM, Kessler P, Dellaire G, Klaholz B, Reina-San-Martin B, Soutoglou E,
Genes Dev. Nov 2014

Conformational plasticity of the Ebola virus matrix protein.
Radzimanowski J, Effantin G, Weissenhorn W,
Protein Sci. Nov 2014

Drug sensing by the ribosome induces translational arrest via active site perturbation.
Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN,
Mol. Cell Nov 2014

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.
Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R,
Nat. Struct. Mol. Biol. Nov 2014

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.
Kannan S, Melesina J, Hauser AT, Chakrabarti A, Heimburg T, Schmidtkunz K, Walter A, Marek M, Pierce RJ, Romier C, Jung M, Sippl W,
J Chem Inf Model Oct 2014

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M,
J. Mol. Biol. Oct 2014

Metrics for comparison of crystallographic maps.
Urzhumtsev A, Afonine PV, Lunin VY, Terwilliger TC, Adams PD,
Acta Crystallogr. D Biol. Crystallogr. Oct 2014

A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin.
Kuznets G, Vigonsky E, Weissman Z, Lalli D, Gildor T, Kauffman SJ, Turano P, Becker J, Lewinson O, Kornitzer D,
PLoS Pathog. Oct 2014

Insights into domain-domain motions in proteins and RNA from solution NMR.
Ravera E, Salmon L, Fragai M, Parigi G, Al-Hashimi H, Luchinat C,
Acc. Chem. Res. Oct 2014

Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.
Meola A, Deville C, Jeffers SA, Guardado-Calvo P, Vasiliauskaite I, Sizun C, Girard-Blanc C, Malosse C, van Heijenoort C, Chamot-Rooke J, Krey T, Guittet E, Pêtres S, Rey FA, Bontems F,
J. Struct. Biol. Oct 2014

Molecular basis for the ribosome functioning as an L-tryptophan sensor.
Bischoff L, Berninghausen O, Beckmann R,
Cell Rep Oct 2014

A fully enzymatic method for site-directed spin labeling of long RNA.
Lebars I, Vileno B, Bourbigot S, Turek P, Wolff P, Kieffer B,
Nucleic Acids Res. Sep 2014

Exploring regions of conformational space occupied by two-domain proteins.
Andrałojć W, Luchinat C, Parigi G, Ravera E,
J Phys Chem B Sep 2014

Cold-active bacteriophages from the Baltic Sea ice have diverse genomes and virus-host interactions.
Senčilo A, Luhtanen AM, Saarijärvi M, Bamford DH, Roine E,
Environ. Microbiol. Aug 2014

Formation of circular polyribosomes on eukaryotic mRNA without cap-structure and poly(A)-tail: a cryo electron tomography study.
Afonina ZA, Myasnikov AG, Shirokov VA, Klaholz BP, Spirin AS,
Nucleic Acids Res. Aug 2014

Dynamic nuclear polarization of (1)H, (13)C, and (59)Co in a tris(ethylenediamine)cobalt(III) crystalline lattice doped with Cr(III).
Corzilius B, Michaelis VK, Penzel SA, Ravera E, Smith AA, Luchinat C, Griffin RG,
J. Am. Chem. Soc. Aug 2014

Cryo-electron microscopy structure of lactococcal siphophage 1358 virion.
Spinelli S, Bebeacua C, Orlov I, Tremblay D, Klaholz BP, Moineau S, Cambillau C,
J. Virol. Aug 2014

Quantifying resolution limiting factors in subtomogram averaged cryo-electron tomography using simulations.
Voortman LM, Vulović M, Maletta M, Voigt A, Franken EM, Simonetti A, Peters PJ, van Vliet LJ, Rieger B,
J. Struct. Biol. Aug 2014

Automated Structural Comparisons Clarify the Phylogeny of the Right-Hand-Shaped Polymerases.
Mönttinen HA, Ravantti JJ, Stuart DI, Poranen MM,
Mol. Biol. Evol. Jul 2014

Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.
Gabel F, Lensink MF, Clantin B, Jacob-Dubuisson F, Villeret V, Ebel C,
Biophys. J. Jul 2014

Solid-state NMR studies of metal-free SOD1 fibrillar structures.
Banci L, Blaževitš O, Cantini F, Danielsson J, Lang L, Luchinat C, Mao J, Oliveberg M, Ravera E,
J. Biol. Inorg. Chem. Jun 2014

Archaeal viruses and bacteriophages: comparisons and contrasts.
Pietilä MK, Demina TA, Atanasova NS, Oksanen HM, Bamford DH,
Trends Microbiol. Jun 2014

The c-ring ion binding site of the ATP synthase from Bacillus pseudofirmus OF4 is adapted to alkaliphilic lifestyle.
Preiss L, Langer JD, Hicks DB, Liu J, Yildiz O, Krulwich TA, Meier T,
Mol. Microbiol. Jun 2014

In cellulo structure determination of a novel cypovirus polyhedrin.
Axford D, Ji X, Stuart DI, Sutton G,
Acta Crystallogr. D Biol. Crystallogr. May 2014

Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design.
Sutkeviciute I, Thépaut M, Sattin S, Berzi A, McGeagh J, Grudinin S, Weiser J, Le Roy A, Reina JJ, Rojo J, Clerici M, Bernardi A, Ebel C, Fieschi F,
ACS Chem. Biol. May 2014

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.
Egan AJ, Jean NL, Koumoutsi A, Bougault CM, Biboy J, Sassine J, Solovyova AS, Breukink E, Typas A, Vollmer W, Simorre JP,
Proc. Natl. Acad. Sci. U.S.A. May 2014

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK,
Nat. Chem. Biol. May 2014

[2Fe-2S] cluster transfer in iron-sulfur protein biogenesis.
Banci L, Brancaccio D, Ciofi-Baffoni S, Del Conte R, Gadepalli R, Mikolajczyk M, Neri S, Piccioli M, Winkelmann J,
Proc. Natl. Acad. Sci. U.S.A. Apr 2014

Purification, characterization and crystallization of the human 80S ribosome.
Khatter H, Myasnikov AG, Mastio L, Billas IM, Birck C, Stella S, Klaholz BP,
Nucleic Acids Res. Apr 2014

Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification.
Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V,
Chem. Biol. Apr 2014

Simultaneous use of solution NMR and X-ray data in REFMAC5 for joint refinement/detection of structural differences.
Rinaldelli M, Ravera E, Calderone V, Parigi G, Murshudov GN, Luchinat C,
Acta Crystallogr. D Biol. Crystallogr. Apr 2014

Probing transient conformational states of proteins by solid-state R(1ρ) relaxation-dispersion NMR spectroscopy.
Ma P, Haller JD, Zajakala J, Macek P, Sivertsen AC, Willbold D, Boisbouvier J, Schanda P,
Angew. Chem. Int. Ed. Engl. Apr 2014

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.
Cousido-Siah A, Ruiz FX, Mitschler A, Porté S, de Lera ÁR, Martín MJ, Manzanaro S, de la Fuente JA, Terwesten F, Betz M, Klebe G, Farrés J, Parés X, Podjarny A,
Acta Crystallogr. D Biol. Crystallogr. Mar 2014

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).
Koehler C, Bonnet J, Stierle M, Romier C, Devys D, Kieffer B,
J. Biol. Chem. Mar 2014

DNP-enhanced MAS NMR of bovine serum albumin sediments and solutions.
Ravera E, Corzilius B, Michaelis VK, Luchinat C, Griffin RG, Bertini I,
J Phys Chem B Mar 2014

Complement is activated by IgG hexamers assembled at the cell surface.
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW,
Science Mar 2014

A general protocol for the generation of Nanobodies for structural biology.
Pardon E, Laeremans T, Triest S, Rasmussen SG, Wohlkönig A, Ruf A, Muyldermans S, Hol WG, Kobilka BK, Steyaert J,
Nat Protoc Mar 2014

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.
Pathare GR, Nagy I, Śledź P, Anderson DJ, Zhou HJ, Pardon E, Steyaert J, Förster F, Bracher A, Baumeister W,
Proc. Natl. Acad. Sci. U.S.A. Mar 2014

The IR-¹⁵N-HSQC-AP experiment: a new tool for NMR spectroscopy of paramagnetic molecules.
Ciofi-Baffoni S, Gallo A, Muzzioli R, Piccioli M,
J. Biomol. NMR Mar 2014

Topical Developments in High-Field Dynamic Nuclear Polarization.
Michaelis VK, Ong TC, Kiesewetter MK, Frantz DK, Walish JJ, Ravera E, Luchinat C, Swager TM, Griffin RG,
Isr. J. Chem. Mar 2014

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin.
Webert H, Freibert SA, Gallo A, Heidenreich T, Linne U, Amlacher S, Hurt E, Mühlenhoff U, Banci L, Lill R,
Nat Commun Jan 2014

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Zhao Y, Ren J, Padilla-Parra S, Fry EE, Stuart DI,
Nat Commun Jan 2014

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.
Maletta M, Orlov I, Roblin P, Beck Y, Moras D, Billas IM, Klaholz BP,
Nat Commun Jan 2014

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants.
Luchinat E, Barbieri L, Rubino JT, Kozyreva T, Cantini F, Banci L,
Nat Commun Jan 2014

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.
Cura V, Troffer-Charlier N, Lambert MA, Bonnefond L, Cavarelli J,
Acta Crystallogr F Struct Biol Commun Jan 2014

The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Myasnikov AG, Afonina ZA, Ménétret JF, Shirokov VA, Spirin AS, Klaholz BP,
Nat Commun Jan 2014

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A,
Nature Jan 2014

Crystal structure of pb9, the distal tail protein of bacteriophage T5: a conserved structural motif among all siphophages.
Flayhan A, Vellieux FM, Lurz R, Maury O, Contreras-Martel C, Girard E, Boulanger P, Breyton C,
J. Virol. Jan 2014

Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.
Zivanovic Y, Confalonieri F, Ponchon L, Lurz R, Chami M, Flayhan A, Renouard M, Huet A, Decottignies P, Davidson AR, Breyton C, Boulanger P,
J. Virol. Jan 2014

SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detail.
Fragai M, Luchinat C, Martelli T, Ravera E, Sagi I, Solomonov I, Udi Y,
Chem. Commun. (Camb.) Jan 2014

Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction.
Snijder J, Burnley RJ, Wiegard A, Melquiond AS, Bonvin AM, Axmann IM, Heck AJ,
Proc. Natl. Acad. Sci. U.S.A. Jan 2014

Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli.
Zhang C, Allegretti M, Vonck J, Langer JD, Marcia M, Peng G, Michel H,
Biochim. Biophys. Acta Jan 2014

Human anamorsin binds [2Fe-2S] clusters with unique electronic properties.
Banci L, Ciofi-Baffoni S, Mikolajczyk M, Winkelmann J, Bill E, Pandelia ME,
J. Biol. Inorg. Chem. Dec 2013

Rescue of maturation off-pathway products in the assembly of Pseudomonas phage φ 6.
Sun X, Pirttimaa MJ, Bamford DH, Poranen MM,
J. Virol. Dec 2013

Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation.
Duval M, Korepanov A, Fuchsbauer O, Fechter P, Haller A, Fabbretti A, Choulier L, Micura R, Klaholz BP, Romby P, Springer M, Marzi S,
PLoS Biol. Dec 2013

TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration.
Rousseau A, McEwen AG, Poussin-Courmontagne P, Rognan D, Nominé Y, Rio MC, Tomasetto C, Alpy F,
PLoS Biol. Dec 2013

Xmipp 3.0: an improved software suite for image processing in electron microscopy.
de la Rosa-Trevín JM, Otón J, Marabini R, Zaldívar A, Vargas J, Carazo JM, Sorzano CO,
J. Struct. Biol. Nov 2013

A pattern matching approach to the automatic selection of particles from low-contrast electron micrographs.
Abrishami V, Zaldívar-Peraza A, de la Rosa-Trevín JM, Vargas J, Otón J, Marabini R, Shkolnisky Y, Carazo JM, Sorzano CO,
Bioinformatics Oct 2013

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules.
Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI,
Biochemistry Oct 2013

On effective and optical resolutions of diffraction data sets.
Urzhumtseva L, Klaholz B, Urzhumtsev A,
Acta Crystallogr. D Biol. Crystallogr. Oct 2013

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.
Cerofolini L, Fields GB, Fragai M, Geraldes CF, Luchinat C, Parigi G, Ravera E, Svergun DI, Teixeira JM,
J. Biol. Chem. Oct 2013

Assessing the conformational changes of pb5, the receptor-binding protein of phage T5, upon binding to its Escherichia coli receptor FhuA.
Breyton C, Flayhan A, Gabel F, Lethier M, Durand G, Boulanger P, Chami M, Ebel C,
J. Biol. Chem. Oct 2013

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase.
Papillon J, Ménétret JF, Batisse C, Hélye R, Schultz P, Potier N, Lamour V,
Nucleic Acids Res. Sep 2013

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP,
Proc. Natl. Acad. Sci. U.S.A. Sep 2013

Mechanism of membranous tunnelling nanotube formation in viral genome delivery.
Peralta B, Gil-Carton D, Castaño-Díez D, Bertin A, Boulogne C, Oksanen HM, Bamford DH, Abrescia NG,
PLoS Biol. Sep 2013

SedNMR: on the edge between solution and solid-state NMR.
Bertini I, Luchinat C, Parigi G, Ravera E,
Acc. Chem. Res. Sep 2013

Particle quality assessment and sorting for automatic and semiautomatic particle-picking techniques.
Vargas J, Abrishami V, Marabini R, de la Rosa-Trevín JM, Zaldivar A, Carazo JM, Sorzano CO,
J. Struct. Biol. Sep 2013

Formation kinetics and structural features of Beta-amyloid aggregates by sedimented solute NMR.
Bertini I, Gallo G, Korsak M, Luchinat C, Mao J, Ravera E,
Chembiochem Sep 2013

Water and protein dynamics in sedimented systems: a relaxometric investigation.
Luchinat C, Parigi G, Ravera E,
Chemphyschem Sep 2013

The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.
Maurer UE, Zeev-Ben-Mordehai T, Pandurangan AP, Cairns TM, Hannah BP, Whitbeck JC, Eisenberg RJ, Cohen GH, Topf M, Huiskonen JT, Grünewald K,
Structure Aug 2013

Automatic comparison and classification of protein structures.
Ravantti J, Bamford D, Stuart DI,
J. Struct. Biol. Jul 2013

TLS from fundamentals to practice.
Urzhumtsev A, Afonine PV, Adams PD,
Crystallogr Rev Jul 2013

Small angle neutron scattering for the study of solubilised membrane proteins.
Breyton C, Gabel F, Lethier M, Flayhan A, Durand G, Jault JM, Juillan-Binard C, Imbert L, Moulin M, Ravaud S, Härtlein M, Ebel C,
Eur Phys J E Soft Matter Jul 2013

Image formation modeling in cryo-electron microscopy.
Vulović M, Ravelli RB, van Vliet LJ, Koster AJ, Lazić I, Lücken U, Rullgård H, Öktem O, Rieger B,
J. Struct. Biol. Jul 2013

Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms.
Simonetti A, Marzi S, Fabbretti A, Hazemann I, Jenner L, Urzhumtsev A, Gualerzi CO, Klaholz BP,
Acta Crystallogr. D Biol. Crystallogr. Jun 2013

Modified coat protein forms the flexible spindle-shaped virion of haloarchaeal virus His1.
Pietilä MK, Atanasova NS, Oksanen HM, Bamford DH,
Environ. Microbiol. Jun 2013

Structure of the archaeal head-tailed virus HSTV-1 completes the HK97 fold story.
Pietilä MK, Laurinmäki P, Russell DA, Ko CC, Jacobs-Sera D, Hendrix RW, Bamford DH, Butcher SJ,
Proc. Natl. Acad. Sci. U.S.A. Jun 2013

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.
Mori M, Massaro A, Calderone V, Fragai M, Luchinat C, Mordini A,
ACS Med Chem Lett Jun 2013

Visualization of redox-controlled protein fold in living cells.
Banci L, Barbieri L, Luchinat E, Secci E,
Chem. Biol. Jun 2013

Atomic-resolution monitoring of protein maturation in live human cells by NMR.
Banci L, Barbieri L, Bertini I, Luchinat E, Secci E, Zhao Y, Aricescu AR,
Nat. Chem. Biol. May 2013

On the development of three new tools for organizing and sharing information in three-dimensional electron microscopy.
Marabini R, Macias JR, Vargas J, Quintana A, Sorzano CO, Carazo JM,
Acta Crystallogr. D Biol. Crystallogr. May 2013

DNA ejection from an archaeal virus--a single-molecule approach.
Hanhijärvi KJ, Ziedaite G, Pietilä MK, Hæggström E, Bamford DH,
Biophys. J. May 2013

Snapshot of haloarchaeal tailed virus genomes.
Senčilo A, Jacobs-Sera D, Russell DA, Ko CC, Bowman CA, Atanasova NS, Österlund E, Oksanen HM, Bamford DH, Hatfull GF, Roine E, Hendrix RW,
RNA Biol May 2013

Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.
Rissanen I, Grimes JM, Pawlowski A, Mäntynen S, Harlos K, Bamford JK, Stuart DI,
Structure May 2013

Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions.
Wang G, Cao RY, Chen R, Mo L, Han JF, Wang X, Xu X, Jiang T, Deng YQ, Lyu K, Zhu SY, Qin ED, Tang R, Qin CF,
Proc. Natl. Acad. Sci. U.S.A. May 2013

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.
Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM,
Proc. Natl. Acad. Sci. U.S.A. May 2013

Imaging protein three-dimensional nanocrystals with cryo-EM.
Nederlof I, Li YW, van Heel M, Abrahams JP,
Acta Crystallogr. D Biol. Crystallogr. May 2013

Lipid fingerprints of intact viruses by MALDI-TOF/mass spectrometry.
Vitale R, Roine E, Bamford DH, Corcelli A,
Biochim. Biophys. Acta Apr 2013

Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis.
Banci L, Bertini I, Calderone V, Ciofi-Baffoni S, Giachetti A, Jaiswal D, Mikolajczyk M, Piccioli M, Winkelmann J,
Proc. Natl. Acad. Sci. U.S.A. Apr 2013

Experimental determination of microsecond reorientation correlation times in protein solutions.
Ravera E, Parigi G, Mainz A, Religa TL, Reif B, Luchinat C,
J Phys Chem B Apr 2013

Studying 18 MDa virus assemblies with native mass spectrometry.
Snijder J, Rose RJ, Veesler D, Johnson JE, Heck AJ,
Angew. Chem. Int. Ed. Engl. Apr 2013

BEST-TROSY experiments for time-efficient sequential resonance assignment of large disordered proteins.
Solyom Z, Schwarten M, Geist L, Konrat R, Willbold D, Brutscher B,
J. Biomol. NMR Apr 2013

The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.
Benoit MP, Imbert L, Palencia A, Pérard J, Ebel C, Boisbouvier J, Plevin MJ,
Nucleic Acids Res. Apr 2013

Insights into head-tailed viruses infecting extremely halophilic archaea.
Pietilä MK, Laurinmäki P, Russell DA, Ko CC, Jacobs-Sera D, Butcher SJ, Bamford DH, Hendrix RW,
J. Virol. Mar 2013

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.
Lutje Hulsik D, Liu YY, Strokappe NM, Battella S, El Khattabi M, McCoy LE, Sabin C, Hinz A, Hock M, Macheboeuf P, Bonvin AM, Langedijk JP, Davis D, Forsman Quigley A, Aasa-Chapman MM, Seaman MS, Ramos A, Poignard P, Favier A, Simorre JP, Weiss RA, Verrips CT, Weissenhorn W, Rutten L,
PLoS Pathog. Mar 2013

Conformational biosensors reveal GPCR signalling from endosomes.
Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M,
Nature Mar 2013

Solution structure and dynamics of human S100A14.
Bertini I, Borsi V, Cerofolini L, Das Gupta S, Fragai M, Luchinat C,
J. Biol. Inorg. Chem. Mar 2013

Dynamic nuclear polarization of sedimented solutes.
Ravera E, Corzilius B, Michaelis VK, Rosa C, Griffin RG, Luchinat C, Bertini I,
J. Am. Chem. Soc. Mar 2013

Structure determination from a single high-pressure-frozen virus crystal.
Burkhardt A, Wagner A, Warmer M, Reimer R, Hohenberg H, Ren J, Fry EE, Stuart DI, Meents A,
Acta Crystallogr. D Biol. Crystallogr. Mar 2013

FASTDEF: fast defocus and astigmatism estimation for high-throughput transmission electron microscopy.
Vargas J, Otón J, Marabini R, Jonic S, de la Rosa-Trevín JM, Carazo JM, Sorzano CO,
J. Struct. Biol. Mar 2013

Plant multifunctional nuclease TBN1 with unexpected phospholipase activity: structural study and reaction-mechanism analysis.
Lipovová P, Podzimek T, Matoušek J, Dušková J, Skálová T, Stěpánková A, Hašek J, Dohnálek J,
Acta Crystallogr. D Biol. Crys Mar 2013

Combined approaches to study virus structures.
Badia-Martinez D, Oksanen HM, Stuart DI, Abrescia NG,
Subcell. Biochem. Jan 2013

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.
Maillot B, Lévy N, Eiler S, Crucifix C, Granger F, Richert L, Didier P, Godet J, Pradeau-Aubreton K, Emiliani S, Nazabal A, Lesbats P, Parissi V, Mely Y, Moras D, Schultz P, Ruff M,
PLoS ONE Jan 2013

Multi-host expression system for recombinant production of challenging proteins.
Meyer S, Lorenz C, Baser B, Wördehoff M, Jäger V, van den Heuvel J,
PLoS ONE Jan 2013

The architecture of human general transcription factor TFIID core complex.
Bieniossek C, Papai G, Schaffitzel C, Garzoni F, Chaillet M, Scheer E, Papadopoulos P, Tora L, Schultz P, Berger I,
Nature Jan 2013

The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism.
Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM,
PLoS ONE Jan 2013

High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.
Nozach H, Fruchart-Gaillard C, Fenaille F, Beau F, Ramos OH, Douzi B, Saez NJ, Moutiez M, Servent D, Gondry M, Thaï R, Cuniasse P, Vincentelli R, Dive V,
Microb. Cell Fact. Jan 2013

Evaluation and use of in-silico structure-based epitope prediction with foot-and-mouth disease virus.
Borley DW, Mahapatra M, Paton DJ, Esnouf RM, Stuart DI, Fry EE,
PLoS ONE Jan 2013

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.
Iourin O, Harlos K, El Omari K, Lu W, Kadlec J, Iqbal M, Meier C, Palmer A, Jones I, Thomas C, Brownlie J, Grimes JM, Stuart DI,
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. Jan 2013

Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
DiMattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT,
Structure Jan 2013

Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
Echalier A, Pan Y, Birol M, Tavernier N, Pintard L, Hoh F, Ebel C, Galophe N, Claret FX, Dumas C,
Proc. Natl. Acad. Sci. U.S.A. Jan 2013

Monolithic ion exchange chromatographic methods for virus purification.
Oksanen HM, Domanska A, Bamford DH,
Virology Dec 2012

Nearest-cell: a fast and easy tool for locating crystal matches in the PDB.
Ramraj V, Evans G, Diprose JM, Esnouf RM,
Acta Crystallogr. D Biol. Crystallogr. Dec 2012

On the use of ultracentrifugal devices for sedimented solute NMR.
Bertini I, Engelke F, Gonnelli L, Knott B, Luchinat C, Osen D, Ravera E,
J. Biomol. NMR Oct 2012

A plate-based high-throughput assay for virus stability and vaccine formulation.
Walter TS, Ren J, Tuthill TJ, Rowlands DJ, Stuart DI, Fry EE,
J. Virol. Methods Oct 2012

PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones.
Boncoeur E, Durmort C, Bernay B, Ebel C, Di Guilmi AM, Croizé J, Vernet T, Jault JM,
Biochemistry Oct 2012

Related haloarchaeal pleomorphic viruses contain different genome types.
Sencilo A, Paulin L, Kellner S, Helm M, Roine E,
Nucleic Acids Res. Jul 2012

Outrunning free radicals in room-temperature macromolecular crystallography.
Owen RL, Axford D, Nettleship JE, Owens RJ, Robinson JI, Morgan AW, Doré AS, Lebon G, Tate CG, Fry EE, Ren J, Stuart DI, Evans G,
Acta Crystallogr. D Biol. Crystallogr. Jul 2012

Engineering rotor ring stoichiometries in the ATP synthase.
Pogoryelov D, Klyszejko AL, Krasnoselska GO, Heller EM, Leone V, Langer JD, Vonck J, Müller DJ, Faraldo-Gómez JD, Meier T,
Proc. Natl. Acad. Sci. U.S.A. Jun 2012

Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1.
Aalto AP, Bitto D, Ravantti JJ, Bamford DH, Huiskonen JT, Oksanen HM,
Proc. Natl. Acad. Sci. U.S.A. May 2012

Closely related archaeal Haloarcula hispanica icosahedral viruses HHIV-2 and SH1 have nonhomologous genes encoding host recognition functions.
Jaakkola ST, Penttinen RK, Vilén ST, Jalasvuori M, Rönnholm G, Bamford JK, Bamford DH, Oksanen HM,
J. Virol. May 2012

Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid.
Kandiba L, Aitio O, Helin J, Guan Z, Permi P, Bamford DH, Eichler J, Roine E,
Mol. Microbiol. May 2012

Virion architecture unifies globally distributed pleolipoviruses infecting halophilic archaea.
Pietilä MK, Atanasova NS, Manole V, Liljeroos L, Butcher SJ, Oksanen HM, Bamford DH,
J. Virol. May 2012

In situ macromolecular crystallography using microbeams.
Axford D, Owen RL, Aishima J, Foadi J, Morgan AW, Robinson JI, Nettleship JE, Owens RJ, Moraes I, Fry EE, Grimes JM, Harlos K, Kotecha A, Ren J, Sutton G, Walter TS, Stuart DI, Evans G,
Acta Crystallogr. D Biol. Crystallogr. May 2012

Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate.
Rennella E, Cutuil T, Schanda P, Ayala I, Forge V, Brutscher B,
J. Am. Chem. Soc. May 2012

Production of UCP1 a membrane protein from the inner mitochondrial membrane using the cell free expression system in the presence of a fluorinated surfactant.
Blesneac I, Ravaud S, Juillan-Binard C, Barret LA, Zoonens M, Polidori A, Miroux B, Pucci B, Pebay-Peyroula E,
Biochim. Biophys. Acta Mar 2012

Non-ionic amphiphilic homopolymers: synthesis, solution properties, and biochemical validation.
Sharma KS, Durand G, Gabel F, Bazzacco P, Le Bon C, Billon-Denis E, Catoire LJ, Popot JL, Ebel C, Pucci B,
Langmuir Mar 2012

MultiBac: expanding the research toolbox for multiprotein complexes.
Bieniossek C, Imasaki T, Takagi Y, Berger I,
Trends Biochem. Sci. Mar 2012

Genetic analysis of MA4079, an aldehyde dehydrogenase homolog, in Methanosarcina acetivorans.
Kliefoth M, Langer JD, Matschiavelli N, Oelgeschläger E, Rother M,
Arch. Microbiol. Mar 2012

An optimized isotopic labelling strategy of isoleucine-γ2 methyl groups for solution NMR studies of high molecular weight proteins.
Ayala I, Hamelin O, Amero C, Pessey O, Plevin MJ, Gans P, Boisbouvier J,
Chem. Commun. (Camb.) Mar 2012

Correlative VIS-fluorescence and soft X-ray cryo-microscopy/tomography of adherent cells.
Hagen C, Guttmann P, Klupp B, Werner S, Rehbein S, Mettenleiter TC, Schneider G, Grünewald K,
J. Struct. Biol. Mar 2012

Solution Structures of PPARγ2/RXRα Complexes.
Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N,
PPAR Res Jan 2012

Oligomeric status and nucleotide binding properties of the plastid ATP/ADP transporter 1: toward a molecular understanding of the transport mechanism.
Deniaud A, Panwar P, Frelet-Barrand A, Bernaudat F, Juillan-Binard C, Ebel C, Rolland N, Pebay-Peyroula E,
PLoS ONE Jan 2012

The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer.
Motta FN, Bastos IM, Faudry E, Ebel C, Lima MM, Neves D, Ragno M, Barbosa JA, de Freitas SM, Santana JM,
PLoS ONE Jan 2012

Perforin activity at membranes leads to invaginations and vesicle formation.
Praper T, Sonnen AF, Kladnik A, Andrighetti AO, Viero G, Morris KJ, Volpi E, Lunelli L, Dalla Serra M, Froelich CJ, Gilbert RJ, Anderluh G,
Proc. Natl. Acad. Sci. U.S.A. Dec 2011

Light it up: highly efficient multigene delivery in mammalian cells.
Trowitzsch S, Klumpp M, Thoma R, Carralot JP, Berger I,
Bioessays Dec 2011

Milled wood lignin: a linear oligomer.
Crestini C, Melone F, Sette M, Saladino R,
Biomacromolecules Nov 2011

Solid-state NMR measurements of asymmetric dipolar couplings provide insight into protein side-chain motion.
Schanda P, Huber M, Boisbouvier J, Meier BH, Ernst M,
Angew. Chem. Int. Ed. Engl. Nov 2011

Rapid measurement of residual dipolar couplings for fast fold elucidation of proteins.
Rasia RM, Lescop E, Palatnik JF, Boisbouvier J, Brutscher B,
J. Biomol. NMR Nov 2011

Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation.
Popoff V, Langer JD, Reckmann I, Hellwig A, Kahn RA, Brügger B, Wieland FT,
J. Biol. Chem. Oct 2011

A new structural model of Aβ40 fibrils.
Bertini I, Gonnelli L, Luchinat C, Mao J, Nesi A,
J. Am. Chem. Soc. Oct 2011

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).
Hare S, Smith SJ, Métifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov P,
Mol. Pharmacol. Oct 2011

From SPINE to SPINE-2 complexes and beyond.
Perrakis A, Daenke S, Stuart DI, Sussman JL,
J. Struct. Biol. Aug 2011

Recording information on protein complexes in an information management system.
Savitsky M, Diprose JM, Morris C, Griffiths SL, Daniel E, Lin B, Daenke S, Bishop B, Siebold C, Wilson KS, Blake R, Stuart DI, Esnouf RM,
J. Struct. Biol. Aug 2011

Automation of large scale transient protein expression in mammalian cells.
Zhao Y, Bishop B, Clay JE, Lu W, Jones M, Daenke S, Siebold C, Stuart DI, Jones EY, Aricescu AR,
J. Struct. Biol. Aug 2011

Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells.
Vijayachandran LS, Viola C, Garzoni F, Trowitzsch S, Bieniossek C, Chaillet M, Schaffitzel C, Busso D, Romier C, Poterszman A, Richmond TJ, Berger I,
J. Struct. Biol. Aug 2011

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.
Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH,
J. Struct. Biol. Aug 2011

Elucidation of lignin structure by quantitative 2D NMR.
Sette M, Wechselberger R, Crestini C,
Chemistry Aug 2011

xtalPiMS: a PiMS-based web application for the management and monitoring of crystallization trials.
Daniel E, Lin B, Diprose JM, Griffiths SL, Morris C, Berry IM, Owens RJ, Blake R, Wilson KS, Stuart DI, Esnouf RM,
J. Struct. Biol. Aug 2011

Nanobody stabilization of G protein-coupled receptor conformational states.
Steyaert J, Kobilka BK,
Curr. Opin. Struct. Biol. Aug 2011

Rational design of a meningococcal antigen inducing broad protective immunity.
Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R,
Sci Transl Med Jul 2011

A systematic mutagenesis-driven strategy for site-resolved NMR studies of supramolecular assemblies.
Amero C, Asunción Durá M, Noirclerc-Savoye M, Perollier A, Gallet B, Plevin MJ, Vernet T, Franzetti B, Boisbouvier J,
J. Biomol. NMR Jul 2011

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions.
Wiedenheft B, van Duijn E, Bultema JB, Bultema J, Waghmare SP, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJ, Heck A, Boekema EJ, Boekema E, Dickman MJ, Dickman M, Doudna JA,
Proc. Natl. Acad. Sci. U.S.A. Jun 2011

13C-labeled heparan sulfate analogue as a tool to study protein/heparan sulfate interactions by NMR spectroscopy: application to the CXCL12α chemokine.
Laguri C, Sapay N, Simorre JP, Brutscher B, Imberty A, Gans P, Lortat-Jacob H,
J. Am. Chem. Soc. Jun 2011

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.
Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso-Iltis C, Moulin M, Haertlein M, Callow P, Mély Y, Svergun DI, Moras D,
Nat. Struct. Mol. Biol. May 2011

The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.
Morris C, Pajon A, Griffiths SL, Daniel E, Savitsky M, Lin B, Diprose JM, da Silva AW, Pilicheva K, Troshin P, van Niekerk J, Isaacs N, Naismith J, Nave C, Blake R, Wilson KS, Stuart DI, Henrick K, Esnouf RM,
Acta Crystallogr. D Biol. Crystallogr. Apr 2011

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.
Reijns MA, Bubeck D, Gibson LC, Graham SC, Baillie GS, Jones EY, Jackson AP,
J. Biol. Chem. Mar 2011

NMR characterization of a "fibril-ready" state of demetalated wild-type superoxide dismutase.
Banci L, Bertini I, Blaževitš O, Cantini F, Lelli M, Luchinat C, Mao J, Vieru M,
J. Am. Chem. Soc. Jan 2011

The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.
Lallous N, Legrand P, McEwen AG, Ramón-Maiques S, Samama JP, Birck C,
PLoS ONE Jan 2011

In-cell NMR in E. coli to monitor maturation steps of hSOD1.
Banci L, Barbieri L, Bertini I, Cantini F, Luchinat E,
PLoS ONE Jan 2011

The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a homohexamer and belongs to the M17 family of metallopeptidases.
Cadavid-Restrepo G, Gastardelo TS, Faudry E, de Almeida H, Bastos IM, Negreiros RS, Lima MM, Assumpção TC, Almeida KC, Ragno M, Ebel C, Ribeiro BM, Felix CR, Santana JM,
BMC Biochem. Jan 2011

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK,
Nature Jan 2011

Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.
Fouillen L, Abdulrahman W, Moras D, Dorsselaer AV, Poterszman A, Sanglier-Cianférani S,
Anal. Biochem. Dec 2010

Microscopic rotary mechanism of ion translocation in the F(o) complex of ATP synthases.
Pogoryelov D, Krah A, Langer JD, Yildiz Ö, Faraldo-Gómez JD, Meier T,
Nat. Chem. Biol. Dec 2010

New functional sulfide oxidase-oxygen reductase supercomplex in the membrane of the hyperthermophilic bacterium Aquifex aeolicus.
Prunetti L, Infossi P, Brugna M, Ebel C, Giudici-Orticoni MT, Guiral M,
J. Biol. Chem. Dec 2010

Crystal structure of the eukaryotic ribosome.
Ben-Shem A, Jenner L, Yusupova G, Yusupov M,
Science Nov 2010

Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import.
Banci L, Bertini I, Cefaro C, Cenacchi L, Ciofi-Baffoni S, Felli IC, Gallo A, Gonnelli L, Luchinat E, Sideris D, Tokatlidis K,
Proc. Natl. Acad. Sci. U.S.A. Nov 2010

Structure and RNA interactions of the plant MicroRNA processing-associated protein HYL1.
Rasia RM, Mateos J, Bologna NG, Burdisso P, Imbert L, Palatnik JF, Boisbouvier J,
Biochemistry Sep 2010

Building macromolecular assemblies by information-driven docking: introducing the HADDOCK multibody docking server.
Karaca E, Melquiond AS, de Vries SJ, Kastritis PL, Bonvin AM,
Mol. Cell Proteomics Aug 2010

Dynamics characterization of fully hydrated bacterial cell walls by solid-state NMR: evidence for cooperative binding of metal ions.
Kern T, Giffard M, Hediger S, Amoroso A, Giustini C, Bui NK, Joris B, Bougault C, Vollmer W, Simorre JP,
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The structure of cbb3 cytochrome oxidase provides insights into proton pumping.
Buschmann S, Warkentin E, Xie H, Langer JD, Ermler U, Michel H,
Science Jul 2010

Structure and interactions of fish type III antifreeze protein in solution.
Salvay AG, Gabel F, Pucci B, Santos J, Howard EI, Ebel C,
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Affinity gradients drive copper to cellular destinations.
Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K, Palumaa P,
Nature Jun 2010

The HADDOCK web server for data-driven biomolecular docking.
de Vries SJ, van Dijk M, Bonvin AM,
Nat Protoc May 2010

Molecular recognition in copper trafficking.
Banci L, Bertini I, McGreevy KS, Rosato A,
Nat Prod Rep May 2010

Stereospecific isotopic labeling of methyl groups for NMR spectroscopic studies of high-molecular-weight proteins.
Gans P, Hamelin O, Sounier R, Ayala I, Durá MA, Amero CD, Noirclerc-Savoye M, Franzetti B, Plevin MJ, Boisbouvier J,
Angew. Chem. Int. Ed. Engl. Mar 2010

Sequence-specific recognition of DNA by the C-terminal domain of nucleoid-associated protein H-NS.
Sette M, Spurio R, Trotta E, Brandizi C, Brandi A, Pon CL, Barbato G, Boelens R, Gualerzi CO,
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Automated unrestricted multigene recombineering for multiprotein complex production.
Bieniossek C, Nie Y, Frey D, Olieric N, Schaffitzel C, Collinson I, Romier C, Berger P, Richmond TJ, Steinmetz MO, Berger I,
Nat. Methods Jun 2009

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies.
Abdulrahman W, Uhring M, Kolb-Cheynel I, Garnier JM, Moras D, Rochel N, Busso D, Poterszman A,
Anal. Biochem. Mar 2009

An efficient protocol for the complete incorporation of methyl-protonated alanine in perdeuterated protein.
Ayala I, Sounier R, Usé N, Gans P, Boisbouvier J,
J. Biomol. NMR Mar 2009

Human initiation factor eIF3 subunit b interacts with HCV IRES RNA through its N-terminal RNA recognition motif.
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FEBS Lett. Jan 2009

Mechanism of Cu(A) assembly.
Abriata LA, Banci L, Bertini I, Ciofi-Baffoni S, Gkazonis P, Spyroulias GA, Vila AJ, Wang S,
Nat. Chem. Biol. Oct 2008

Structure of the 30S translation initiation complex.
Simonetti A, Marzi S, Myasnikov AG, Fabbretti A, Yusupov M, Gualerzi CO, Klaholz BP,
Nature Sep 2008

Perspectives on NMR in drug discovery: a technique comes of age.
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Toward the characterization of peptidoglycan structure and protein-peptidoglycan interactions by solid-state NMR spectroscopy.
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Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.
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Protein production and purification.
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Nat. Methods Mar 2008

The structural biology and genomics platform in strasbourg: an overview.
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Methods Mol. Biol. Jan 2008

Automated recombinant protein expression screening in Escherichia coli.
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Methods Mol. Biol. Jan 2008

Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.
Banci L, Bertini I, Durazo A, Girotto S, Gralla EB, Martinelli M, Valentine JS, Vieru M, Whitelegge JP,
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Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.
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J. Gen. Virol. Jun 2007

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Nat. Struct. Mol. Biol. Mar 2007

Structural genomics of the Epstein-Barr virus.
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Acta Crystallogr. D Biol. Crystallogr. Oct 2006

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.
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The impact of protein characterization in structural proteomics.
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Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.
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Recombinant protein expression and solubility screening in Escherichia coli: a comparative study.
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Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.
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Eukaryotic expression: developments for structural proteomics.
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Information-driven protein-DNA docking using HADDOCK: it is a matter of flexibility.
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Nucleic Acids Res. Jan 2006

Structural genomics of eukaryotic targets at a laboratory scale.
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J. Struct. Funct. Genomics Jan 2005

A role for chromatin remodeling in transcriptional termination by RNA polymerase II.
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Mol. Cell Dec 2002

Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli.
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The structure of the translational initiation factor IF1 from E.coli contains an oligomer-binding motif.
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