Where, what, who
- Instruct Centres
- Centre for Bioinformatics
- Centre for Computational Biology
- Centre for Image Processing
- Centre for Mass Spectrometry
- Bijvoet Center - Utrecht
- LCT MS (2) at the Bijvoet Center in Utrecht, Netherlands
- LCT MS at the Bijvoet Center in Utrecht, Netherlands
- Q-ToF (modified) at the Bijvoet Center in Utrecht, Netherlands
- Q-ToF MS (2) (modified) at the Bijvoet Center in Utrecht, the Netherlands
- Q-ToF MS (3) (modified) at the Bijvoet Center in Utrecht, the Netherlands
- Synapt HDMS at the Bijvoet Center in Utrecht, Netherlands
- Xevo HDX MS at the Bijvoet Center in Utrecht, Netherlands
- HADDOCK at the Bijvoet Centre in Utrecht, Netherlands
- Oxford Mass Spectrometry Centre
- Bijvoet Center - Utrecht
- Centre for Protein Production
- Centre for Solid State NMR
- Centre for Virus Production
- Instruct Centre - France 2
- AnalyticalUltracentrifugation at IBS Grenoble France
- Cryo EM on Polara in Grenoble, France
- Grenoble SPR
- In vitro production of RNA & proteins - IBS -Grenoble
- Isotopic labelling for NMR
- Mass Spectrometry Platform at IBS, Grenoble
- Membrane Protein Purification Platform (MP3)
- Multi Angle / Dynamic Light Scattering at IBS Grenoble France
- Instruct Centre - Germany 2
- Goethe University - Frankfurt
- MPIBP - Frankfurt
- Crystal Screening Station at the MPI of Biophysics in Frankfurt, Germany
- Data collection station at the MPI of Biophysics in Frankfurt, Germany
- Differential Scanning Calorimeter at the MPI of Biophysics in Frankfurt, Germany
- Differential Scanning Fluorimeter at the MPI of Biophysics in Frankfurt, Germany
- ESI-q-TOF mass spectrometer at the MPI of Biophysics in Frankfurt, Germany
- Isothermal Titration Calorimeter at the MPI of Biophysics in Frankfurt, Germany
- MALDI TOF/TOF mass spectrometer at the MPI of Biophysics in Frankfurt, Germany
- Rigaku CrystalMation System at the MPI of Biopysics
- Instruct Centre - Italy
- Biobank in Florence, Italy
- Bioinformatic and computational structural biology tools in Florence, Italy
- EPR at CERM in Florence, Italy
- Fast Field Cycling Relaxometry at CERM in Florence, Italy
- Multi Angle / Dynamic Light Scattering at CERM in Florence, Italy
- Solid State NMR at CERM in Florence, Italy
- Solution NMR at CERM in Florence, Italy
- Surface Plasmon Resonance (SPR) in Florence, Italy
- Instruct Centre - United Kingdom
- Instruct Centre - France 1
- 600 MHz liquid-state NMR at IGBMC-CERBM (Strasbourg), France)
- 700 MHz liquid-state NMR at IGBMC-CERBM (Strasbourg), France
- Bioinformatics Target Characterization at IGBMC-CERBM Strasbourg
- Bioinformatics phylogenetic profiling at IGBMC-CERBM Strasbourg
- Bioinformatics protein complex analysis at IGBMC-CERBM Strasbourg
- Circular Dichroism at IGBMC-CERBM Strasbourg
- Correlative Light and Electron Microscopy at IGBMC-CERBM Strasbourg
- Cryo Electron Microscopy at IGBMC-CERBM Strasbourg
- Cryo Electron Microscopy on Tecnai F20 at IGBMC-CERBM Strasbourg
- Electron microscopy at IGBMC-CERBM Strasbourg
- Expression in Yeast at IGBMC-CERBM Strasbourg
- Expression in bacteria at IGBMC-CERBM Strasbourg
- Expression in insect cells at IGBMC-CERBM Strasbourg
- Expression in mammalian cells at IGBMC-CERBM Strasbourg
- High Throughput Crystallisation at IGBMC-CERBM in Strasbourg
- In-house X-ray source at IGBMC-CERBM Strasbourg
- Isothermal Titration Calorimetry at IGBMC-CERBM Strasbourg
- Light Microscopy at IGBMC-CERBM Strasbourg
- Purification: chromatographic system at IGBMC-CERBM Strasbourg
- Purification: lysis system at IGBMC-CERBM Strasbourg
- Thermal shift assay at IGBMC-CERBM Strasbourg
- solution NMR at IGBMC-CERBM Strasbourg
- Analytical UltraCentrifugation at IGBMC-CERBM Strasbourg
- Instruct Centre - EMBL
- Instruct Centre - Israel
- Bacterial Production of Proteins
- Cryo-electron Microscopy at Weizmann Institute of Science in Rehovot, Israel
- Production of proteins in baculovirus
- Protein Crystallization at the ISPC in Rehovot, Israel
- Protein Production in Mammalian cells
- Protein Purification
- The ISPC Protein Production Facility in Rehovot, Israel
- Instruct Centre - Germany 1
- Correlative Light and Electron Microscopy at the MPI of Biochemistry in Martinsried, Germany
- Cryo-electron microscopy at the MPI of Biochemistry in Martinsried, Germany
- Cryo-electron microscopy on Tecnai F20 at the MPI of Biochemistry in Martinsried, Germany
- Cryo-electron microscopy on Tecnai F30 Polara at the MPI of Biochemistry in Martinsried, Germany
- Cryo-electron microscopy on Titan Krios at the MPI of Biochemistry in Martisried, Germany
- National Affiliate Centres
- Countries
- Organisations
- Architecture et Fonction des Macromolécules Biologiques
- Bijvoet Center, Utrecht University
- Biology Centre ASCR
- Bruker AXS
- CEA
- CNRS
- CSIRO Materials Science and Engineering
- EMBL-EBI UK
- Fourmentin-Guilbert Scientific Foundation
- Fundação para a Ciência e a Tecnologia
- Inserm
- Instituto de Salud Carlos III
- John Innes Centre
- Karlsruhe Institute of Technology
- New University of Lisbon
- Spronk NMR Consultancy
- Universidade Técnica de Lisboa
- Universidade de Coimbra
- Universidade de Lisboa
- Universidade de Lisboa
- Universidade do Porto
- University of Algarve
- University of Auckland
- University of Aveiro
- University of Helsinki
- University of Oslo
- University of Portsmouth
- University of Verona
- Åbo Akademi University
- Networks
- Lead Instruct Scientists
- Members
- Publications
- A role for chromatin remodeling in transcriptional termination by RNA polymerase II.
- Characterizing a monotopic membrane enzyme.Biochemical,enzymaticand crystallization studies on A aeolicus sulfid
- Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large...
- Genetic analysis of MA4079, an aldehyde dehydrogenase homolog, in Methanosarcina acetivorans.
- Microscopic rotary mechanism of ion translocation in the F(o) complex of ATP synthases.
- Protein production and purification.
- Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).
- Structural and energetic basis for H+ versus Na+ binding selectivity in ATP synthase Fo rotors.
- Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides at 2.65 A resolution: cofactors...
- The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.
- The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration.
- The structure of cbb3 cytochrome oxidase provides insights into proton pumping.
- A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
- A comparison of inoculation methods to simplify recombinant protein expression screening in Escherichia coli.
- A disulfide bridge allows for site-selective binding in liver bile Acid binding protein
- A multidomain flexible docking approach to deal with large conformational changes in the modeling of biomolecular complexes.
- A new structural model of aβ(40) fibrils.
- A non-invasive method based on saliva to characterize transthyretin in amyloidotic patients using FT-ICR high-resolution MS.
- A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies.
- Ab initio crystallographic structure determination of insulin from protein to electron density without crystal handling.
- Affinity gradients drive copper to cellular destinations.
- Agarose as crystallisation media for proteins II: trapping of gel fibres into the crystals.
- Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions.
- An efficient non-mediated amperometric biosensor for nitrite determination.
- An inventory of the bacterial macromolecular components and their spatial organization.
- Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.
- Analytical ultracentrifugation for the study of protein association and assembly.
- Anoncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides
- Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview.
- Automated recombinant protein expression screening in Escherichia coli.
- Automated system for high-throughput protein production using the dialysis cell-free method.
- Automated unrestricted multigene recombineering for multiprotein complex production.
- Automation of large scale transient protein expression in mammalian cells.
- Bacillus subtilis aconitase is an RNA-binding protein.
- Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel.
- Biophysical and atomic force microscopy characterization of the RNA from satellite tobacco mosaic virus.
- Building macromolecular assemblies by information-driven docking: introducing the HADDOCK multibody docking server.
- CORM-3 reactivity toward proteins: the crystal structure of a Ru(II) dicarbonyl-lysozyme complex.
- CPORT: a consensus interface predictor and its performance in prediction-driven docking with HADDOCK.
- CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland.
- Capillary crystallization and molecular-replacement solution of haemoglobin II from the clam Lucina pectinata.
- Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.
- Co-expression of protein complexes in prokaryotic and eukaryotic hosts
- CoESPRIT: a library-based construct screening method for identification and expression of soluble protein complexes.
- Construction of a set Gateway-based destination vectors for high-throughput cloning and expression screening in E. coli.
- Cooperative use of cytochrome cd1 nitrite reductase and its redox partner
- Correlative microscopy: bridging the gap between fluorescence light microscopy and cryo-electron tomography.
- Cryo-electron tomography of cells: connecting structure and function.
- Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase
- Crystal structure of a cellulosomal family 3 carbohydrate esterase from C thermocellum
- Crystal structure of the eukaryotic ribosome.
- Crystallization of the membrane protein hVDAC1 produced in cell-free system.
- Crystallization of the membrane-containing bacteriophage PRD1 in quartz capillaries by vapour diffusion.
- Design and structure of stapled peptides binding to estrogen receptors.
- Differences between CusA and AcrB crystallisation highlighted by protein flexibility.
- Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli.
- Dynamics of amyloid β fibrils revealed by solid-state NMR.
- ESPRIT: an automated, library-based method for mapping and soluble expression of protein domains from challenging targets.
- Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly.
- Eukaryotic expression: developments for structural proteomics.
- Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function.
- Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization.
- Experimental evidence for the stability of the depletion zone around a growing protein crystal under microgravity.
- Expression of Helicobacter pylori CagA domains by library-based construct screening.
- Expression of a chloroplast ATP/ADP transporter in E. coli membranes: behind the Mistic strategy.
- Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.
- Expression of vascular endothelial growth factor (VEGF) transcript and protein in the testis of several vertebrates
- Extending the host range of Listeria monocytogenes by rational protein design.
- FILTREST3D: discrimination of structural models using restraints from experimental data.
- FRankenstein becomes a cyborg: the automatic recombination and realignment of fold recognition models in CASP6.
- Family 6 carbohydrate-binding modules display multiple beta1,3-linked glucan-specific binding interfaces.
- Fine-tuning the π-π Aromatic Interactions in Peptides: Somatostatin Analogues Containing Mesityl Alanine.
- From words to literature in structural proteomics.
- Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.
- Gd(III) Chelates as NMR Probes of Protein-Protein Interactions. Case Study: Rubredoxin and Cytochrome c(3).
- Glycoprotein prod for struc analysis with stable,glycosylation mutant CHOcell lines established by fluorescence-act cell sorting
- Granada Crystallisation Box: a new device for protein crystallisation by counter-diffusion techniques.
- HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.
- High throughput construction and small scale expression screening of multi-tag vectors in Escherichia coli.
- High-chloride concentrations abolish the binding of adenine nucleotides in the mitochondrial ADP/ATP carrier family.
- Hormone affinity and fibril formation of piscine transthyretin: the role of the N-terminal.
- Hybrid molecular structure of the giant protease tripeptidyl peptidase II.
- Identification of a DNA-binding site for the transcription factor Haa1, required for S cerevisiae response to acetic acid stress
- Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.
- Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI.
- In-situ measurement of rocking curves during lysozyme crystal growth.
- Information-driven protein-DNA docking using HADDOCK: it is a matter of flexibility.
- Insights into the molecular architecture of the 26S proteasome.
- Intermediates in the assembly pathway of the double-stranded RNA virus phi6.
- Library-based methods for identification of soluble expression constructs.
- Life in the fast lane for protein crystallization and X-ray crystallography.
- Light it up: highly efficient multigene delivery in mammalian cells.
- MARINE-EXPRESS: taking advantage of high throughput cloning and expression strategies for the post-genomic
- MODOMICS: a database of RNA modification pathways.
- Measuring the cytochrome C nitrite reductase activity-practical considerations on the enzyme assays.
- Mechanism of Cu(A) assembly.
- MetaMQAP: a meta-server for the quality assessment of protein models.
- Metabolic biomarkers of prenatal disorders
- Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible mechanism for familial ALS.
- Micromachining tools and correlative approaches for cellular cryo-electron tomography.
- Mol chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import.
- Molecular recognition in copper trafficking.
- MultiBac: expanding the research toolbox for multiprotein complexes.
- Multiscale imaging of neurons grown in culture: from light microscopy to cryo-electron tomography.
- Nitrite Biosensing via Selective Enzymes-A Long but Promising Route.
- ORF-selector ESPRIT: A second generation library screen for soluble protein expression employing open reading frame selection.
- On the molecular basis of uracil recognition in DNA
- Paramagnetism-basedNMR restraintsmaximum allowed probabilities for the conformations of partially independent prot domains.
- Perspectives on NMR in drug discovery: a technique comes of age.
- Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes.
- Probabilistic cross-link analysis and experiment planning for high-throughput elucidation of protein structure.
- Protein Identification Using Nano-HPLC-MS: ESI-MS and MALDI-MS Interfaces.
- Protein crystallization by capillary counterdiffusion for applied crystallographic structure determination.
- Purification, crystallization and preliminary X-ray analysis of mexicain.
- Purification,crystallization and preliminary X-ray characterization of the pentamodular arabinoxylanase CtXyl5A from C thermo
- Rational design of a meningococcal antigen inducing broad protective immunity.
- Recombinant heptameric coatomer complexes: novel tools to study isoform-specific functions.
- Recombinant protein expression and solubility screening in Escherichia coli: a comparative study.
- Recording information on protein complexes in an information management system.
- Recovering lost magnetization: polarization enhancement in biomolecular NMR.
- Relations between structure and function of the mitochondrial ADP/ATP carrier.
- Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells.
- Self-protection and survival of arbovirus-infected mosquito cells.
- Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 c binding module.
- Snapshots of nuclear pore complexes in action captured by cryo-electron tomography.
- Solid-state NMR spectroscopic investigation of Aβ protofibrils
- Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.
- Structural analysis of T thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides new insight
- Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex.
- Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers.
- Structural genomics of eukaryotic targets at a laboratory scale.
- Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis.
- Structural insights into eRF3 and stop codon recognition by eRF1.
- Structure and function of an arabinoxylan-specific xylanase.
- Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.
- Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit.
- Structure of Burkholderia cepacia UGD BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.
- Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ.
- Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.
- Structure of tetragonal hen egg-white lysozyme at 0.94 A from crystals grown by the counter-diffusion method.
- Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.
- Structure of the 30S translation initiation complex.
- Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.
- Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica.
- SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells.
- Systems for the cell-free synthesis of proteins.
- THUMP from archaeal tRNA:m22G10 methyltransferase, a genuine autonomously folding domain.
- The HADDOCK web server for data-driven biomolecular docking.
- The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.
- The crystal structure of Cupriavidus necator nitrate reductase in oxidized and partially reduced states.
- The future is hybrid.
- The impact of protein characterization in structural proteomics.
- The impact of structural proteomics on biotechnology.
- The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.
- The molecular sociology of the cell.
- The native 3D organization of bacterial polysomes.
- The progress made in determining the Mycobacterium tuberculosis structural proteome.
- The structural basis for cap binding by influenza virus polymerase subunit PB2.
- The structural biology and genomics platform in strasbourg: an overview.
- The three-dimensional organization of polyribosomes in intact human cells.
- The unique architecture of Bunyamwera virus factories around the Golgi complex.
- Three-dimensional structure of Rubella virus factories.
- Understanding the polymorphic behaviour of a mutant of the α-spectrin SH3 domain by means of two 1.1 Å resolution structures.
- Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
- Virus factories: associations of cell organelles for viral replication and morphogenesis.
- Visualization of proteins in intact cells with a clonable tag for electron microscopy.
- WAVe: web analysis of the variome.
- X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases.
- Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains.
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