Instruct Centre CZ > BIOCEV

Czech Infrastructure for Integrative Structural Biology


Flagship Service/Technology

Native Mass Spectrometry, Vestec near Prague, Czech Republic

Structural mass spectrometry (MS3D) offers various methodologies for characterization of protein structure. IBT/CMS at BIOCEV offers different labelling approaches including hydrogen/deuterium exchange, covalent labelling, chemical cross-linking and limited proteolysis. The facility is equipped with cutting-edge technologies including high-resolution mass spectrometer, HPLC system, H/D system and in-house software for data processing. The service provided includes data processing and reporting ready for publication. Besides, the platform also offers: Identification and quantification of proteins, Precise determination of protein molecular mass, Characterization of various posttranslational modifications.

View All Mass Spectrometry at Instruct



CIISB - Czech Infrastructure for Integrative Structural Biology is formed by two Centers of Excellence for Structural Biology constructed within two projects: CEITEC – Central European Institute of Technology, Brno and BIOCEV - Biotechnology and Biomedicine Centre, Vestec, Prague-West. CEITEC and BIOCEV have been financed by the EU Structural Funds through the Operational Program Research and Development for Innovation, priority axis 1 – European Centers of Excellence, which is managed by the Ministry of Education, Youth and Sports of the Czech Republic. The Czech structural biology community is represented by the Czech Society for Structural Biology (CSSB), which is forming a national link to INSTRUCT. CIISB affiliation with INSTRUCT contributes to the development of human resources in research, attracts qualified national and international researchers, and enables efficient dissemination of knowledge and expertise within INSTRUCT, as well as the efficient use of the infrastructure.

BIOCEV Core facilities (CF) for Integrative Structural Biology

The core facilities for structural biology in BIOCEV are organized under the Centre of molecular structure, run by the Institute of Biotechnology, Czech Academy of Sciences.

The Centre of Molecular Structure (CMS) encompasses several laboratories providing a complex approach to studies of three-dimensional structure, function and biophysical properties of biological molecules.

Visit This Centre

The BIOCEV building is located just outside of Prague. It can be easily reached by car or public transport. You will find detailed information on how to get to BIOCEV HERE.


  • Loading Publication Data (Identifier: 29092908)
  • Loading Publication Data (Identifier: 30002097)
  • Loading Publication Data (Identifier: 29248681)
  • Loading Publication Data (Identifier: 30544181)
  • Loading Publication Data (Identifier: 30348313)
  • Loading Publication Data (Identifier: 29239122)
  • Loading Publication Data (Identifier: 29233912)
  • Loading Publication Data (Identifier: 29580999)

Visit this centre and more by submitting a proposal for access.

Submit Proposal

Scientific Contacts

  • Jan Dohnálek login to contact
  • Bohdan Schneider login to contact

Admin Contacts

  • Jan Dohnálek login to contact
  • Magdalena Schneiderová login to contact

Technical Contacts

  • Jiri Pavlicek login to contact
  • Tatsiana Charnavets login to contact
  • Petr Pompach login to contact
  • Jan Stránský login to contact