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Core Center for NMR: Experts in solution and solid-state NMR for the functional characterization of biomolecules.

Instruct Centre IT

Flagship Service/Technology

Solution NMR, CERM/CIRMMP, Florence, Italy

CERM/CIRMMP offers unique research capabilities in the field of Solution NMR of biomolecules providing state of the art instrumentation and expertise to perform, at the highest level, the most comprehensive array of experiments needed for the structure and dynamic characterization of biological macromolecules and their complexes. To attain fundamental atomic level information, all the standard pulse sequences for spectroscopic, structural and dynamical characterization are available. We develop 13C direct detection protocols for “protonless” NMR experiments and for in-cell NMR spectroscopy, and tailored pulse sequences for structural determination of paramagnetic systems.  



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Instruct Centre IT

The Magnetic Resonance Center (CERM) is a “center for research, transfer and higher education" at the University of Florence. CERM together with the Interuniversity Consortium (CIRMMP), constitute an infrastructure for Life Sciences, which provides a unique environment for research in the field of Structural Biology. The infrastructure is specialized in structural biology, molecular biology, protein/complex structure determination, functional characterization, drug discovery, structure-based vaccine design, bioinformatics, NMR methodology, relaxometry and metabolomics.


The Center has a wide range of high-resolution spectrometers, for solution and solid-state NMR, ranging from 400 MHz to 950 MHz and equipped with several probes to meet all conceivable experimental conditions.  On the low field end it offers unique instruments for the measurement of nuclear relaxation at various magnetic fields with a Fast Field Cycling Relaxometer. CERM/CIRMMP makes accessible also all its broad range of tools for biomolecules biophysical characterization such as EPR spectrometers, multi-angle/dynamic light scattering, calorimeter, CD, etc. Wet lab facilities are available for preparation of samples.


CERM provides integrated databases, software and web-based tools for genome browsing, macromolecular structure calculation based on NMR data with/without the inclusion of paramagnetic constraints, analysis of metal-binding sites and metalloproteins. CERM is also the promoter of a biobank of biological samples and biomolecular resources (including plasmids and strains for protein production).

The CERM/CIRMMP NMR infrastructure has provided access to European users since 1994. In more recent years (FP6 and FP7 programs) has provided expertise and a mean of over 260 days per year of transnational access, through projects Eu-NMR, East-NMR, Bio-NMR, of which was coordinator, and iNEXT.

Visit This Centre

The CERM building is located on Polo Scientifico campus in Sesto Fiorentino, a small town close to Florence airport. The site can be easily reached by car or bus. For details, look at the following linkThe site entrance of CERM is located in Via Luigi Sacconi 6.

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Visit this centre and more by submitting a proposal for access.

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Scientific Contacts

  • Lucia Banci login to contact
  • Simone Ciofi-Baffoni login to contact

Admin Contacts

  • Francesca Morelli login to contact

Technical Contacts

  • Rebecca Del Conte login to contact