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Instruct Centre - France 1

The Strasbourg center provides a cutting-edge technological environment for integrative structural biology approaches, from the molecular to the cellular level, with an emphasis on protein production linked with preparation of samples for EM and crystallography.

PROTEIN PRODUCTION

Protein engineering and production are essential tools for structural, biophysical and functional studies as well as for biotechnology and medical applications. The Strasbourg center offers a state-of-the-art infrastructure for the production of biomolecules and biomolecular complexes in E. coli, yeast, insect cells (baculovirus expression system) as well as in mammalian cells using an attenuated vaccinia virus vector. The Strasbourg platform has a unique expertise on production of recombinant multi-protein complexes as well as on purification of endogenous complexes using the TAP-tag technology in yeast.

STRUCTURE DETERMINATION

Strasbourg provides core-technologies for structure determination by crystallography, cryo-EM and tomography. Strasbourg is a center of expertise for crystrallographic analysis of protein-protein and protein-nucleic acid complexes (nano and micro-automated screening and HTP crystal production, data collection and structure determination) and cryo-electron microscopy/tomography (Hight resolution cryo-EM, cryo electron tomography using up to date equipment (Polara and Titan microscopes and Falcon detectors)

The center also offers access to

- biophysical plateform to monitor protein properties and function, including protein stability, protein complex formation, oligomerisation and protein interactions,

- shape determination by SAXS.

- NMR (700MHz, 600MHz with cryo-probe, protein and nucleic acid isotope labelling, solution structure determination & dynamics, translational diffusion measurement)

Visit This Centre

Welcome to IGBMC Srasbourg, France.

You will find information on "Travelling to IGBMC" from the link below:

http://www.igbmc.fr/igbmc/plan/

To find advice on "Life in Strasbourg" you can download a pdf file from here:

http://archive.igbmc.fr/igbmc/LifeInStrasbourg.pdf

Publications

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Scientific Contacts

• Alberto Podjarny
• Jean Cavarelli

Admin Contacts

• Marie-Christine Poterszman email hidden

Technical Contacts

• Catherine Birck email hidden