France 2 - The platforms of the Institut de Biologie Structurale managed by Integrated Structural Biology Grenoble (ISBG).
The Biophysics platform at ISBG & IBS, Grenoble offers one of the largest ensemble of state-of-the-art technic & methods for in vitro characterizing the intrinsic properties of biological macromolecules in solution, biomolecular interactions and their assemblages.
The platform is organised of several technical plateaus managed by scientists, engineers and technicians with technical and methodological savoir-faire & expertise, in order to help any scientist to tackle variety of biological questions and projects (stability, homogeneity, oligomeric states, stoechiomoetry, specificity, affinity, kinetics, thermodynamics...).
The platform and its instruments are available for the entire scientific Instruct-ERIC community.
For more details on plateaus, instruments, experts and how to apply & access, please visit the platform webpage : http://www.isbg.fr/caracterisa...
The Cellular Imaging platform grants the access to a confocal microscope (spinning disk S-M4D), a video-microscope (V-M4D), and a flow-cytometer (VYB). The instruments are optimized to study living cells. Details are available on the ISBG website.
3 electron microscopes:
High resolution single particle EM. K2 summit direct electron detector. Latitude S software for automated data collection
F20: cryoEM, cryo Tomo and negative staining. CETA camera
T12: negative staining, cellular EM Orius camera
ESPRIT: Screening of tens of thousands of constructs of a single gene to identify well-behaving soluble constructs.
The mass spectrometry (MS) platform provides the scientific community a service for protein analysis and characterization and offers the following analytical techniques : Determination of exact mass, at high resolution, for intact proteins and peptides Control of protein and peptide expression, modification, mutation and labeling Analyses of protein limited proteolysis Analysis of macromolecular complexes by native MS.
Visit this centre and more by submitting a proposal for access.Submit Proposal