Instruct-ERIC Events

Presentation by Alejandro Buschiazzo. Institute Pasteur Montevideo. How do bacteria sense their environment? …kinases and regulators on the move

Conference
Date: 22-Sep-2017

Contact: Claudia Alen Amaro

Instruct

The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases was uncovered, through direct crystallographic observation of a bona fide complex between a histidine-kinase (HK) and its response regulator (RR) from Bacillus subtilis. This HK:RR binary complex was crystallised in two different signalling states by using state-stabilising point-mutants of the kinase. To the best of our knowledge these are the first near-atomic resolution structures of such complexes from a mesophilic bacterial species. 

Wellcome Trust Centre for Human Genetics. Roosevelt Drive. OX3 7BN, United Kingdom

Presentation by Alejandro Buschiazzo. Institute Pasteur Montevideo. How do bacteria sense their environment? …kinases and regulators on the move