Featuring expert speakers from Instruct Centres across Europe, Instruct-ERIC Webinar Series: Structure Meets Function highlights some of the latest developments in structural biology, demonstrating how integrative methods are enabling scientists to decipher the mechanisms that underpin health and disease.
Watch the first webinar in the series here.
The second webinar in the series will be hosted by Instruct Centre IT on 18 September 2020, 11:00 - 12:30 CEST.
Talk 1: Drug screening by in-cell NMR
Speaker: Enrico Luchinat
Abstract: In-cell NMR can provide unique insights on the structure and function of macromolecules in a cellular setting. At CERM, we developed an in-cell NMR approach to monitor ligand binding in human cells in real time, providing critical information on the cell penetrance and binding selectivity of potential drugs.
Talk 2: 1.2 GHz NMR applied to Sars-CoV2 proteins
Speaker: Francesca Cantini
Abstract: The global outbreak of SARS-CoV2 viral infection is associated with the absence of specific drug(s) or vaccines able to fight it. The knowledge of the structural properties of SARS-CoV2 viral proteins is strategic in this effort and the 1.2 GHz NMR spectrometer, recently installed at CERM, has been strategic to unravel atomic-level structural details of proteins involved in the SARS-CoV2 lifecycle and to identify strategies to interfere with the disease.
Talk 3: SS NMR of functionalised biomaterials
Speaker: Marco Fragai
Abstract: The characterization of proteins embedded in matrices or conjugated with biocompatible polymers to produce biotherapeutics represents a major challenge for structural biology. We have several examples where the use of solid-state NMR alone or integrated with solution NMR data and x-ray crystallography allowed a detailed structural characterisation of these heterogeneous systems.