Instruct-ERIC Events

Training course: X-Ray Methods in Structural Biology

Registration Date: 07-Apr-2019 to 15-Jun-2019
Date: 15-Oct-2019 to 31-Oct-2019

Contact: Anastassis Perrakis

X-ray crystallography has been the cornerstone of structural biology for half a century, and remains the technique of choice for atomic resolution understanding of macromolecules and for structure guided drug discovery. This intense course combines laboratory and computational instruction to train course participants in the major techniques used to determine three-dimensional structures. It is designed for scientists with a working knowledge of protein structure and function, but who are new to macromolecular crystallography or who wish to increase their in-depth knowledge of macromolecular crystallography. 

Topics to be covered include:

  • Basic diffraction theory
  • Crystallisation (proteins, nucleic acids, complexes and membrane proteins)
  • Synchrotron X-ray sources and optics
  • Data collection and processing
  • Structure solution by experimental phasing methods (SAD, MAD, MIR, and others) and molecular replacement
  • Electron density maps improvement
  • Model building and refinement
  • Structure validation
  • Coordinate deposition
  • Structure presentation

This immersive course is an outstanding place to learn both the theoretical and practical aspects of Macromolecular Crystallography, combining extensive lectures from world-renowned teachers, with hands-on experiments. For more information about the course, financial support, and to apply, click here.

New York, United States

Training course: X-Ray Methods in Structural Biology