University of Oulu one of Instruct-ERIC Centres have an opening for a fixed-term, full-time Doctoral student position in research project headed by Professor Lari Lehtiö in the Protein and Structural Biology research unit, Faculty of Biochemistry and Molecular Medicine. The position is supervised by professor Lehtiö and is focused on structural and functional characterization of human tankyrases as well as in development of small molecule inhibitors as tools and as potential future drug leads.
Their team focuses on structure, function and selective inhibition of proteins involved in signaling through ADP-ribosylation – a post translational modification affecting protein stability, function and interactions in multiple cellular pathways. We use X-ray crystallography, small angle X-ray scattering, cryoEM and other biophysical techniques to study the structure and function of these, often multidomain proteins, work. We develop assays suitable for high-throughput screening of inhibitors and use structural information for more rational design to develop specific inhibitors that can be used as chemical probes to study the functions of the proteins and in some cases to validate them as drug targets. Protein X-ray crystallography is our main tool used to understand structure-activity relationships of compounds. For more information, please see web pages and twitter
Applications must be submitted using the electronic application form by January 20th, 2021 (23:59Finnish local time, EET), with the following attachments as three separate pdf files:
Complete CV containing contact information of at least two referees (Max. size limit of the attachment: 5 Mbytes)
Motivation letter (maximum 1 page) describing prior knowledge and research interests and career plans (1-2 pages; max. size limit of the attachment: 2 Mbytes).
Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. If the original documents are not in English, Finnish or Swedish, each document must be accompanied by an official certified translation into English or Finnish. (Max. size limit of the attachment: 2 Mbytes)
For further information please contact Professor Lari Lehtiö, e-mail: lari.lehtio (at) oulu.fi