Five postdoctoral positions are available in The Molecular Basis of Disease Section (MBDS), Center for Structural Biology (CSB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Frederick, MD. The candidate will perform basic research in molecular biology/structural biology/biochemistry.
The MBDS group uses mixed structural methods to study host-pathogen interactions and other medically important molecular pathways with a particular focus on membrane resident protein complexes. We use and develop cutting-edge structural methods including cryo-electron microscopy and X-ray crystallography to define molecular mechanisms involved in health and disease states.
The research of the group is supported by the collaborative and interdisciplinary NIH intramural program, which includes more than 1100 labs and provides state-of-the-art equipment in structural biology, biochemistry, and biophysics. These core facilities are supported by Ph.D. level staff and offer hands-on training. In addition, NIH is committed to the continuing education and career development of its research staff through numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES). There are also opportunities for intramural career transition funding (K grants).
Interested candidates must have a Ph.D. or M.D. degree with less than 5 years of postdoctoral experience. Applicants must have a strong background in molecular biology, structural biology, biochemistry, or a related discipline. The candidate should have good oral and written skills in English. The candidate should be skilled in at least one of the following areas: Biochemistry and molecular biology (experience in protein purification from different expression systems of soluble and membrane proteins); Electron microscopy (experience in cryo-EM sample preparation and digital image processing). We have excellent access to high-end microscopes (Titan Krios/Cold FEG/Selectris / Falcon IV, Arctica/BioQuantum/K3 and Aquilos II CryoFIB available locally in addition to smaller testing microscopes); Crystallography (experience in protein crystal structure determination). We have excellent access to Synchrotron beamlines and in-house X-ray diffraction and SAXS cores.
The candidate must be highly motivated to participate in rigorous and innovative research programs and possess excellent work ethic and team spirit, be able to work independently and efficiently and collaborate closely with members of the group, and other labs on joint projects.
The research group is supported by the collaborative and interdisciplinary NIH intramural and offers competitive salary and comprehensive health insurance. Appointments will be one year initially and renewable up to a total of 3-5 years based on performance. The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.
Interested applicants should send a cover letter indicating preferred starting date, a brief description (1-2 pages) of past research, CV, and contact information for at least three references via email to Susan Lea D.Phil.: LeaLabRecruit@nih.gov). More information about MBDS can be found at: https://ccr.cancer.gov/center-for-structural-biology/susan-m-lea. The Center for Structural Biology is located on the Frederick campus of NCI in Frederick, Maryland, USA. Frederick was founded in 1745 and is a city of ~70,000 inhabitants, 45 minutes from the central NIH, Bethesda Campus. Surrounded by State Parks, you can ski within 30 minutes of the campus in the winter and enjoy the many wineries, breweries and other thriving, independent, hostelries in the summer.