Instruct Biennial

Structural Biology Conference

Structural Biology: Deeper into the Cell

22nd - 24th May, 2019

Alcala de Henares, Madrid, Spain

The 4th Instruct Biennial Structural Biology Conference will take place in Alcalá de Henares, Spain, from May 22 till May 24, 2019. The historical Alcalá de Henares was the original location of the Universidad Complutense, founded in 1293 and one of the oldest universities in the world, as well as being the birthplace of Miguel de Cervantes. The social programme of the meeting will include a visit to the city, a gala dinner and extensive opportunities to network with the Instruct Structural Biology community.

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Julia Mahamid

Structural and Computational Biology Unit, European Molecular Biology Laboratory

Sjors Scheres

MRC Laboratory of Molecular Biology

Poul Nissen

Aarhus University

Eva Pereiro

ALBA Synchrotron

Teresa Carlomagno

Leibniz University Hannover, Helmholtz Centre for Infection Research

Ada Yonath

Weizmann Institute

Hashim M Al-Hashimi

Duke University, School of Medicine

Andrej Sali

University of California, San Francisco

Dave Stuart

Instruct-ERIC, University of Oxford

Dorit Hanein

Institut Pasteur

Brent Nannenga

Arizona State University

Patrick England

Institut Pasteur

Instruct is a distributed European Research Infrastructure, which provides scientists with access to all major cutting edge technologies that enable biomacromolecular structure determination at atomic resolution. Access to all of these technologies has been available to European member researchers from February 2012.

The inaugural Instruct Structural Biology Meeting at Heidelberg in 2013 successfully showcased integrative structural biology and its impact on biological research and biomedicine. The second Biennial took place in Florence in 2015 continuing the integrative line with an increased focus on innovation. The last edition which took place in Brno in the Czech Republic included sessions representing recent structural biology highlights, emerging methods and technologies and results of biomedical importance. We have already confirmed outstanding speakers for this 4th edition and we are looking forward to see you there.

Registration Fees:

€65 for participants from Instruct Countries

€450 for participants from non-Instruct Countries

This will cover attendance, coffee breaks, lunch and conference gala. There will be additional costs for accommodation.

Abstract Submission Deadlines:

Abstract submission: March 1st 2019 | Registration closed: April 1st 2019 | Student fellowship: March 1st 2019

Organising Committee

Day 1 - Wednesday 22nd May

Satellite Events

Women in Science

16:00 - 19:00
22nd May

Instruct-Ultra General Assembly

13:00 - 16:00
22nd May

Instruct-ERIC Manager Workshop

13:00 - 16:00
22nd May

20:00Dinner at the Parador de Alcala

Day 2 - Thursday 23rd May

Session 1: Structural Biology towards Cellular Biology: Integrating Biology

(Chairs: Dave Stuart, Jose Maria Carazo)

09:00-09:25Ada Yonath (Weizmann Institute)
09:30-09:55Julia Mahamid (EMBL Heidleberg)Molecular Views into Cellular Function by in situ Cryo-Electron Tomography
10:00-10:25Dorit Hanein (Institut Pasteur)Unravelling cancer cell nanoarchitecture through multiscale imaging; Coupling molecular activation, biosensors and its functional output
11:00-11:25Talk selected from abstract
12:00-12:25Presentation of the Ivano Bertini award

Session 2: Structural Biology and Health: Current Challenges

(Chairs: Ada Yonath, Stephen Cusack)

14:30-14:55Sjors Scheres (MRC)Structures of tau filaments extracted from the brains of individuals with Alzheimer's and Pick's disease
15:00-15:25Talk selected from abstract
16:00-16:25Poul Nissen (Aarhus University)Structure and Dynamics of Membrane Transport Proteins
16:30-16:55Talk selected from abstract
17:00-18:00Poster session & Drinks (Even number posters)
18:00-19:00Poster session & Drinks (Odd number posters)
20:00Conference Gala

Day 3 - Friday 24th May

Session 3: Emerging Technologies in Integrative Structural Biology

(Chairs: Margarida Archer, Vladimir Sklenar)

09:00-09:25Andrej Sali (UCSF)Integrative Structural Biology
09:30-09:55Hashim M Al-Hashimi (Duke University)Visualizing the invisible genome: Fleeting structures of DNA in gene expression and genome stability
10:00-10:25Eva Pereiro (ALBA)Correlative X-ray imaging of cells
11:00-11:25Talk selected from abstract
11:30-11:55Patrick England (Institut Pasteur)Molecular-scale biophysics methods for sample quality control and quantitative characterisation
12:00-12:25Teresa Carlomagno (Leibniz University Hannover)Studying multicomponent complexes by integrative structural biology

Session 4: New Trends

(Chairs: )

14:00-14:25Brent Nannenga (Arizona State University)Structure determination by microcrystal electron diffraction
14:30-14:55Alex De Marco (Monash University)On High Throughput sample preparation for Cryo EM
15:00-15:25Dave Stuart (University of Oxford)Instruct
15:30-16:00Poster prize presentation and closing address


Getting to Alcalá de Henares

Alcalá de Henares can be reached easily from Madrid by train.

From the airport (Barajas Madrid international airport) using subway and train:

A train to Alcalá de Henares can be taken at Nuevos Ministerios station. To go there, you must first take the subway (“Metro”) at the airport. It is located in the middle of Terminal T2 (corridor connecting to Parking P2, 1st floor). The subway station is called Aeropuerto. You can find it on the map here.

Nuevos Ministerios is also a train station, where you must take the RENFE urban train (“CERCANÍAS”) to Alcalá de Henares. There are three lines connecting Nuevos Ministerios with Alcalá de Henares (lines C-1, C-2 and C-7). More information is available from the RENFE website.

From the airport (Barajas Madrid international airport) by taxi:

You can also take a taxi from the airport to your hotel in Alcalá; it will take you 30 minutes to get there which is less than half of the time you will need by train.

From Chamartin station:

You must take the RENFE urban train (“CERCANÍAS”) to Alcalá de Henares.There are three lines connecting Chamartin with Alcalá de Henares (lines C-1, C-2 and C-7).

Venue: Parador de Alcalá

17th-century monastery school and student lodgings located in the former San Jerónimo College centrally located in this world heritage city.

Dirección: Colegios, 8 28801 Alcalá de Henares Madrid+34 918880330 +34 918880527

We have had reports of phishing attempts relating to accommodation bookings. If you're unsure of any email communications, please contact us.


Student Fellowship applications are invited from graduate students.

Fellowships will cover economy travel costs plus accommodation for 2 nights.

  • Applicants should be pre-doctoral scientists (PhD students).
  • The applicant’s home institution (applicant’s usual workplace) must be within an Instruct Member country.
  • Recipients must submit a 500 word short report on their conference experience by 1st March 2019.

Applicants should send a copy of the abstract submitted upon registration and a 200 word statement justifying their application and a letter of recommendation from their supervisor to

The deadline for Fellowship applications is 1st March 2019.

Ivano Bertini Award

The Ivano Bertini Award recognises a significant achievement in frontier research that utilises an integrative structural biology approach. The first recipient of the award was Stephen Cusack FRS, Head of EMBL Outstation in Grenoble. His work on the structure of protein-RNA complexes and proteins involved in host-pathogen responses is ground-breaking and exemplifies the power of using integrated technology approaches in research.

The Award is the first commemorating Ivano Bertini who developed powerful new methods in NMR and built up a world class Centre for Magnetic Resonance (CERM) in Florence. CERM was in the first group of major Centres in structural biology to form the core structure of Instruct.

The Award of €15,000 is endowed by Bruker BioSpin which, together with Ivano, developed NMR instrumentation to broaden its application and increase measurement sensitivity.

For more information and to apply, please follow the Bertini award link.

Confidentiality Policy

Confidentiality and Use of Information

All material presented at the IBSBC2019, including abstracts, oral presentations and posters, must be treated as personal communication and should be cited only with the consent of the author.

Photography or video/audio recording of oral presentations or individual posters is strictly prohibited unless with explicit consent of the meeting organisers and the author.

The content of abstracts, oral and poster presentations are the responsibility of the author(s). Instruct will publish the content of the submitted abstracts without asking for explicit consent from the author(s).

Social Media

We encourage participants to blog, tweet or otherwise communicate about the meeting (#IBSBC2019). However, dissemination of results or discussion presented at the meeting to anonymous third parties must obtain permission from the presenting author BEFORE communicating any results or discussion to third party groups, message boards, blogs or other online resources (other than your own lab or departments).

If you have specific questions regarding these issues or any other aspects of the conference, please contact the IBSBC2019 organising team. Send a message to or call us at +44 1865 98 86 39 to speak with one of our team.