CCP-BioSim is the Collaborative Computational Project for Biomolecular Simulation which was established to strengthen, promote and develop biomolecular simulation at the life sciences interface. CCP-BioSim is an inclusive wide-ranging project, bringing together chemists, physicists and chemical engineers as well as researchers from all branches of ‘molecule-oriented’ biochemistry and biology. CCP-BioSim develops and provides training and tools to lower the barrier to non-experts becoming proficient and productive users of biomolecular simulation techniques. We also work to develop and apply advanced methods. Engagement with experimentalists is crucial to ensure that the methodologies delivered are relevant to biological problems.